This study aimed to explore the role of melatonin in oxidative stress-induced injury on retinal
ganglion cells and the underlying mechanisms. The immortalized RGC-5 cells were treated …

Age‐related macular degeneration (AMD) affects the retinal macula and results in loss of
vision, and AMD is the primary cause of blindness and severe visual impairment among …

High energy-consumption in retinal pigmented epithelium (RPE) cells poses oxidative stress
(OS) and contributes to mitochondrial dysfunction (MD) for retinal degeneration-associated …

Oxidative stress is defined as a disturbance in the prooxidant–antioxidant balance, leading
to potential cell damage. Reactive oxygen species such as superoxide radicals, hydroxyl …

Retinal ischemia–reperfusion (RIR) injury caused by high intraocular pressure (IOP) is an
important risk factor contributing to retinal ganglion cell (RGC) death, eventually causing …

Optic neuropathies refer to the dysfunction or degeneration of optic nerve fibers caused by
any reasons including ischemia, inflammation, trauma, tumor, mitochondrial dysfunction …

Oxidative stress triggers ocular neurodegenerative diseases, such as glaucoma or macular
degeneration. The increase of reactive oxygen and nitrogen species in retinal ganglion cells …

The excessive apoptosis of retinal nerve cells (RNCs) could cause a variety of retinal
neurodegenerative diseases which could result in the irreversible blindness. In this study …

OBJECTIVE: To investigate the roles and underlying mechanisms of melatonin in oxygen-
glucose deprivation/reoxygenation (OGD/R)-insulted SH SY5Y cells. MATERIALS AND …

Acute ocular hypertension (AOH) is the most important characteristic of acute glaucoma,
which can lead to retinal ganglion cell (RGC) death and permanent vision loss. So far …