Rethinking Click and Bioorthogonal Chemistry for Biomedical Applications

V Delplace - ACS Materials Letters, 2023 - ACS Publications
Over the last two decades, click chemistry and bioorthogonal chemistry have revolutionized
the field of biomedical engineering. Extensive investigations have been conducted and …

Recent advances in bioorthogonal click chemistry for biomedical applications

A Battigelli, B Almeida, A Shukla - Bioconjugate Chemistry, 2022 - ACS Publications
Bioorthogonal click chemistry, first introduced in the early 2000s, has become one of the
most widely used approaches for designing advanced biomaterials for applications in tissue …

Click and bioorthogonal chemistry: the future of active targeting of nanoparticles for nanomedicines?

L Taiariol, C Chaix, C Farre, E Moreau - Chemical Reviews, 2021 - ACS Publications
Over the years, click and bioorthogonal reactions have been the subject of considerable
research efforts. These high-performance chemical reactions have been developed to meet …

[HTML][HTML] Clicking in harmony: exploring the bio-orthogonal overlap in click chemistry

G Singh, R Singh, G Singh, J Stanzin, H Singh… - RSC …, 2024 - pubs.rsc.org
In the quest to scrutinize and modify biological systems, the global research community has
continued to explore bio-orthogonal click reactions, a set of reactions exclusively targeting …

[HTML][HTML] A special virtual issue celebrating the 2022 Nobel Prize in Chemistry for the development of click chemistry and bioorthogonal chemistry

C Bertozzi - ACS Central Science, 2022 - ACS Publications
In the late 1990s, my fledgling lab at UC Berkeley contemplated a new type of chemistry that
could be performed in living systems cells, model organisms, human patients for various …

Clicked'drugs: researchers prove the remarkable chemistry in humans

M Peplow - Nat. Biotechnol, 2023 - nature.com
Click chemistry therapeutics are increasingly drawing attention from investors and big
pharma. Shasqi announced in June that it is collaborating with Johnson & Johnson …

Bio-orthogonal click chemistry for in vivo bioimaging

B Liu - Trends in Chemistry, 2019 - cell.com
The rapid advancement of bio-orthogonal click chemistry in the past decade has enabled
the study and precise manipulation of biological processes within living organisms. The …

[HTML][HTML] Mutually Orthogonal Bioorthogonal Reactions: Selective Chemistries for Labeling Multiple Biomolecules Simultaneously

KR Venrooij, L de Bondt, KM Bonger - Topics in Current Chemistry, 2024 - Springer
Bioorthogonal click chemistry has played a transformative role in many research fields,
including chemistry, biology, and medicine. Click reactions are crucial to produce …

Click Chemistry: Reaction Rates and Their Suitability for Biomedical Applications

T Luu, K Gristwood, JC Knight, M Jörg - Bioconjugate Chemistry, 2024 - ACS Publications
Click chemistry has become a commonly used synthetic method due to the simplicity,
efficiency, and high selectivity of this class of chemical reactions. Since their initial discovery …

Deciphering life sciences with “live” chemistry—The 2022 Nobel Prize in Chemistry

X Fan, PR Chen - Science China. Chemistry, 2023 - search.proquest.com
The 2022 Nobel Prize in Chemistry was awarded to Carolyn R. Bertozzi, Morten Meldal and
K. Barry Sharpless for their development of click reaction and bioorthogonal chemistry. Our …