Effect of APOE4 allele and gender on the rate of atrophy in the Hippocampus, entorhinal cortex, and fusiform gyrus in alzheimer's disease

EA Hamza, AA Moustafa, R Tindle… - Current Alzheimer …, 2022 - ingentaconnect.com
Background: The hippocampus, entorhinal cortex, and fusiform gyrus are brain areas that
deteriorate during early-stage Alzheimer's disease (AD). The ApoE4 allele has been …

The impact of APOE ɛ4 in Alzheimer's Disease differs according to age

J Kim, S Park, H Yoo, H Jang, Y Kim… - Journal of …, 2018 - content.iospress.com
We evaluated how the impact of apolipoprotein E4 (APOE4) differs according to age in
Alzheimer's disease (AD) patients. We recruited 846 AD patients and 815 cognitively normal …

Impact of APOE on the healthy aging brain: a voxel-based MRI and DTI study

RA Honea, E Vidoni, A Harsha… - Journal of Alzheimer's …, 2009 - content.iospress.com
Neuroimaging studies of apolipoprotein E (ApoE4) have implicated its association with brain
atrophy in Alzheimer's disease. To date, few studies have used automated morphological …

Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study

L O'Dwyer, F Lamberton, S Matura, C Tanner… - PloS one, 2012 - journals.plos.org
The E4 allele of the ApoE gene has consistently been shown to be related to an increased
risk of Alzheimer's disease (AD). The E4 allele is also associated with functional and …

APOEε2 is Associated with Milder Clinical and Pathological Alzheimer's Disease

K Jindal, A Bansal - Annals of Neurosciences, 2016 - karger.com
Background Alzheimer's disease (AD) is one of the forms of dementia, which affects> 25
million people around the world. AD is not restricted to developed or developing nations; …

A multi-cohort study of ApoE ɛ4 and Amyloid-β effects on the hippocampus in Alzheimer's disease

W Khan, V Giampietro, T Banaschewski… - Journal of …, 2017 - content.iospress.com
The apolipoprotein E (APOE) gene has been consistently shown to modulate the risk of
Alzheimer's disease (AD). Here, using an AD and normal aging dataset primarily consisting …

Association of APOE ε4 with cerebral gray matter volumes in non-demented older adults: The MEMENTO cohort study

M Regy, A Dugravot, S Sabia, A Fayosse, JF Mangin… - NeuroImage, 2022 - Elsevier
Abstract Data on 2,045 non-demented individuals with memory complaints were drawn from
the Memento cohort study to examine the association between Apolipoprotein E ε4 allele …

APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's disease

M Pievani, S Galluzzi, PM Thompson, PE Rasser… - Neuroimage, 2011 - Elsevier
Prior studies reported that the hippocampal volume is smaller in Alzheimer's disease
patients carrying the Apolipoprotein E ε4 allele (APOE4) versus patients who are non …

Apolipoprotein e4 affects topographical changes in hippocampal and cortical atrophy in Alzheimer's disease dementia: A five-year longitudinal study

YJ Kim, H Cho, YJ Kim, CS Ki… - Journal of …, 2015 - content.iospress.com
Apolipoprotein E4 (APOE4) is a genetic risk factor for developing Alzheimer's disease (AD).
Once AD manifests clinically, however, the effects of APOE4 are less clear. Therefore, we …

The APOE4 effect: structural brain differences in Alzheimer's disease according to the age at symptom onset

G Forno, J Contador, A Pérez‐Millan… - European Journal of …, 2023 - Wiley Online Library
Background and purpose How the APOE genotype can differentially affect cortical and
subcortical memory structures in biomarker‐confirmed early‐onset (EOAD) and late‐onset …