Endothelial cells in the pathogenesis of pulmonary arterial hypertension

CE Evans, ND Cober, Z Dai… - European Respiratory …, 2021 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is a devastating disease that involves pulmonary
vasoconstriction, small vessel obliteration, large vessel thickening and obstruction, and …

[HTML][HTML] Endothelial dysfunction in pulmonary hypertension: cause or consequence?

K Kurakula, VFED Smolders, O Tura-Ceide… - Biomedicines, 2021 - mdpi.com
Pulmonary arterial hypertension (PAH) is a rare, complex, and progressive disease that is
characterized by the abnormal remodeling of the pulmonary arteries that leads to right …

Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series)

B Ranchoux, LD Harvey, RJ Ayon… - Pulmonary …, 2018 - journals.sagepub.com
Endothelial dysfunction is a major player in the development and progression of vascular
pathology in pulmonary arterial hypertension (PAH), a disease associated with small vessel …

Endothelial cell dysfunction and cross talk between endothelium and smooth muscle cells in pulmonary arterial hypertension

M Humbert, D Montani, F Perros, P Dorfmüller… - Vascular …, 2008 - Elsevier
The pathogenesis of pulmonary arterial hypertension (PAH) involves a complex and
multifactorial process in which endothelial cell dysfunction appears to play an integral role in …

Adaptation and remodelling of the pulmonary circulation in pulmonary hypertension

M Vaillancourt, G Ruffenach, J Meloche… - Canadian Journal of …, 2015 - Elsevier
Pulmonary arterial hypertension (PAH) is characterized by remodelling of pulmonary
arteries caused by a proliferation/apoptosis imbalance within the vascular wall. This …

New molecular targets of pulmonary vascular remodeling in pulmonary arterial hypertension: importance of endothelial communication

C Guignabert, L Tu, B Girerd, N Ricard, A Huertas… - Chest, 2015 - Elsevier
Pulmonary arterial hypertension (PAH) is a disorder in which mechanical obstruction of the
pulmonary vascular bed is largely responsible for the rise in mean pulmonary arterial …

[HTML][HTML] Phenotypic diversity of vascular smooth muscle cells in pulmonary arterial hypertension: implications for therapy

B Lechartier, N Berrebeh, A Huertas, M Humbert… - Chest, 2022 - Elsevier
Pulmonary arterial hypertension (PAH) is a progressive incurable condition that is
characterized by extensive remodeling of the pulmonary circulation, leading to severe right …

Focus on early events: pathogenesis of pulmonary arterial hypertension development

O Rafikova, I Al Ghouleh, R Rafikov - Antioxidants & redox signaling, 2019 - liebertpub.com
Significance: Pulmonary arterial hypertension (PAH) is a progressive disease of the lung
vasculature characterized by the proliferation of all vascular wall cell types, including …

Cellular and molecular pathobiology of pulmonary arterial hypertension

M Humbert, NW Morrell, SL Archer… - Journal of the American …, 2004 - jacc.org
Pulmonary arterial hypertension (PAH) has a multifactorial pathobiology. Vasoconstriction,
remodeling of the pulmonary vessel wall, and thrombosis contribute to increased pulmonary …

Endothelial dysfunction in pulmonary hypertension

R Budhiraja, RM Tuder, PM Hassoun - Circulation, 2004 - Am Heart Assoc
occur in patients with idiopathic PPH. 6, 7 Whether these cells are derived from the
endothelial progenitor cells obtained from the mobilization of bone marrow by growth factors …