Das Metabolic Engineering ermöglicht es, mikrobielle Stämme zu konstruieren, die
Chemikalien effektiv überproduzieren. Allerdings nutzen die Produktionsstämme Substrate …

Flow-injection mass spectrometry (FI-MS) enables metabolomics studies with a very high
sample-throughput. In most FI-MS methods, samples are directly injected into the …

Ein häufiges Problem bei Metabolic-Engineering-Projekten ist es, Enzymkonzentrationen zu
finden, die die Produktivität und Effizienz von synthetischen Stoffwechselwegen verbessern …

Temperature‐sensitive (TS) mutants are a unique tool to perturb and engineer cellular
systems. Here, we constructed a CRISPR library with 15,120 Escherichia coli mutants, each …

E. coli is the host of choice to produce a wide variety of chemicals and proteins. Overflow
metabolism is considered as the widespread and major obstacle in microbial synthesis, and …

Microbial metabolism can be harnessed to produce a broad range of industrially important
chemicals. Often, three key process variables: Titer, Rate and Yield (TRY) are the target of …

Systems metabolic engineering, which recently emerged as metabolic engineering
integrated with systems biology, synthetic biology, and evolutionary engineering, allows …

Most large-scale biological processes, like global element cycling or decomposition of
organic matter, are mediated by microbial consortia. Commonly, the different species in such …

Microorganisms are small but efficient micro-factories for producing bulk and value-added
products. Systems biology and synthetic biology advanced during the last decade are …

Metabolic Engineering to Produce Fine Chemicals in <i>Escherichia coli</i>: DSM Biotech
GmbH Page 1 B4.04 Abhängigkeit der metabolischen Flussverteilungen von Glucose und …