Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

DM Howard, MJ Adams, TK Clarke, JD Hafferty… - Nature …, 2019 - nature.com
Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

NR Wray, S Ripke, M Mattheisen, M Trzaskowski… - Nature …, 2018 - nature.com
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

A genome-wide association study of depressive symptoms

K Hek, A Demirkan, J Lahti, A Terracciano, A Teumer… - Biological …, 2013 - Elsevier
BACKGROUND: Depression is a heritable trait that exists on a continuum of varying severity
and duration. Yet, the search for genetic variants associated with depression has had few …

[PDF][PDF] Uncovering the genetic architecture of major depression

AM McIntosh, PF Sullivan, CM Lewis - Neuron, 2019 - cell.com
There have been several recent studies addressing the genetic architecture of depression.
This review serves to take stock of what is known now about the genetics of depression, how …

Genetics of depression: progress at last

N Mullins, CM Lewis - Current psychiatry reports, 2017 - Springer
Abstract Purpose of Review We will describe the success of recent genome-wide
association studies that identify genetic variants associated with depression and outline the …

Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies

N Cai, KW Choi, EI Fried - Human molecular genetics, 2020 - academic.oup.com
With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …

An analysis of two genome-wide association meta-analyses identifies a new locus for broad depression phenotype

N Direk, S Williams, JA Smith, S Ripke, T Air… - Biological …, 2017 - Elsevier
Background The genetics of depression has been explored in genome-wide association
studies that focused on either major depressive disorder or depressive symptoms with …

Transcriptome-wide association study identifies new susceptibility genes and pathways for depression

X Li, X Su, J Liu, H Li, M Li… - Translational …, 2021 - nature.com
Depression is the most prevalent mental disorder with substantial morbidity and mortality.
Although genome-wide association studies (GWASs) have identified multiple risk variants …

Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in> 1.2 million individuals highlight new therapeutic directions

DF Levey, MB Stein, FR Wendt, GA Pathak… - Nature …, 2021 - nature.com
Major depressive disorder is the most common neuropsychiatric disorder, affecting 11% of
veterans. Here we report results of a large meta-analysis of depression using data from the …

The genetics of depression: successful genome-wide association studies introduce new challenges

J Ormel, CA Hartman, H Snieder - Translational psychiatry, 2019 - nature.com
The recent successful genome-wide association studies (GWASs) for depression have
yielded more than 80 replicated loci and brought back the excitement that had evaporated …