Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …
mood and anhedonia. Depression has a heritable component that has remained difficult to …
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
A genome-wide association study of depressive symptoms
BACKGROUND: Depression is a heritable trait that exists on a continuum of varying severity
and duration. Yet, the search for genetic variants associated with depression has had few …
and duration. Yet, the search for genetic variants associated with depression has had few …
[PDF][PDF] Uncovering the genetic architecture of major depression
There have been several recent studies addressing the genetic architecture of depression.
This review serves to take stock of what is known now about the genetics of depression, how …
This review serves to take stock of what is known now about the genetics of depression, how …
Genetics of depression: progress at last
Abstract Purpose of Review We will describe the success of recent genome-wide
association studies that identify genetic variants associated with depression and outline the …
association studies that identify genetic variants associated with depression and outline the …
Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies
With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
An analysis of two genome-wide association meta-analyses identifies a new locus for broad depression phenotype
Background The genetics of depression has been explored in genome-wide association
studies that focused on either major depressive disorder or depressive symptoms with …
studies that focused on either major depressive disorder or depressive symptoms with …
Transcriptome-wide association study identifies new susceptibility genes and pathways for depression
X Li, X Su, J Liu, H Li, M Li… - Translational …, 2021 - nature.com
Depression is the most prevalent mental disorder with substantial morbidity and mortality.
Although genome-wide association studies (GWASs) have identified multiple risk variants …
Although genome-wide association studies (GWASs) have identified multiple risk variants …
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in> 1.2 million individuals highlight new therapeutic directions
Major depressive disorder is the most common neuropsychiatric disorder, affecting 11% of
veterans. Here we report results of a large meta-analysis of depression using data from the …
veterans. Here we report results of a large meta-analysis of depression using data from the …
The genetics of depression: successful genome-wide association studies introduce new challenges
The recent successful genome-wide association studies (GWASs) for depression have
yielded more than 80 replicated loci and brought back the excitement that had evaporated …
yielded more than 80 replicated loci and brought back the excitement that had evaporated …