The evolution of milk casein genes from tooth genes before the origin of mammals

K Kawasaki, AG Lafont, JY Sire - Molecular biology and …, 2011 - academic.oup.com
Caseins are among cardinal proteins that evolved in the lineage leading to mammals. In
milk, caseins and calcium phosphate (CaP) form a huge complex called casein micelle. By …

Comparative aspects of milk caseins

MR Ginger, MR Grigor - Comparative Biochemistry and Physiology Part B …, 1999 - Elsevier
The caseins comprise the major protein component of milk of most mammals and are
secreted as micelles that also carry high concentrations of calcium. They are …

Organization of the bovine casein gene locus

M Rijnkels, PM Kooiman, HA De Boer… - Mammalian …, 1997 - search.proquest.com
In bovine milk, four types of caseins (O~ s~-, cts2-, 13-, and K-casein) have been identified,
each encoded by a single copy gene. For each of these, several genetic variants have been …

Characterisation of monotreme caseins reveals lineage-specific expansion of an ancestral casein locus in mammals

CM Lefèvre, JA Sharp… - Reproduction, Fertility and …, 2009 - CSIRO Publishing
Using a milk-cell cDNA sequencing approach we characterised milk-protein sequences from
two monotreme species, platypus (Ornithorhynchus anatinus) and echidna (Tachyglossus …

κ-Casein-deficient mice fail to lactate

PC Shekar, S Goel, SDS Rani… - Proceedings of the …, 2006 - National Acad Sciences
Acquisition of milk production capabilities by an ancestor of mammals is at the root of
mammalian evolution. Milk casein micelles are a primary source of amino acids and calcium …

[HTML][HTML] Caseins: Versatility of their micellar organization in relation to the functional and nutritional properties of milk

A Runthala, M Mbye, M Ayyash, Y Xu, A Kamal-Eldin - Molecules, 2023 - mdpi.com
The milk of mammals is a complex fluid mixture of various proteins, minerals, lipids, and
other micronutrients that play a critical role in providing nutrition and immunity to newborns …

Multispecies comparison of the casein gene loci and evolution of casein gene family

M Rijnkels - Journal of mammary gland biology and neoplasia, 2002 - Springer
Caseins, the major milk proteins, are present in a genomic cluster spanning 250–350 kb.
The divergence at the coding level between human, rodent, and cattle sequences is rather …

Recent studies on nucleotide sequences encoding the caseins

J Bonsing, AG Mackinlay - Journal of Dairy Research, 1987 - cambridge.org
The caseins represent the major protein fraction in the milks of most species (Jenness,
1979). In bovine milk these consist of the three Ca-sensitive caseins, asl-, as2-and/?-casein …

Mineralized tissue and vertebrate evolution: the secretory calcium-binding phosphoprotein gene cluster

K Kawasaki, KM Weiss - Proceedings of the National …, 2003 - National Acad Sciences
Gene duplication creates evolutionary novelties by using older tools in new ways. We have
identified evidence that the genes for enamel matrix proteins (EMPs), milk caseins, and …

Structure and expression of the mouse casein gene locus

M Rijnkels, DA Wheeler, HA De Boer, FR Pieper - Mammalian genome, 1997 - Springer
The analysis of yeast artificial chromosomes (YACs) containing the complete mouse casein
gene locus revealed the presence of five casein genes, α-, ß-, γ-, δ-, and κ-casein, in this …