From the beginning, induced pluripotent stem cell (iPSC) technology was touted as a path to
improve our understanding of disease biology and enable drug discovery. Advances in …

Abstract Development of effective therapeutics for neurological disorders has historically
been challenging partly because of lack of accurate model systems in which to investigate …

Adult-onset neurodegenerative diseases are among the most difficult human health
conditions to model for drug development. Most genetic or toxin-induced cell and animal …

The systematic generation of neurons from patients with neurological disorders can provide
important insights into disease pathology, progression and mechanism. This review will …

Developing efficient models for neurological diseases enables us to uncover disease
mechanisms and develop therapeutic strategies to treat them. Discovery of reprogramming …

Brain disorders, from neurodegenerative to psychiatric disorders, are among the most
challenging conditions to study because of the intricate nature of the human brain and the …

Introduction: Although intensive efforts have been made, effective treatments for
neurodegenerative and neurodevelopmental diseases have not been yet discovered …

The ability to use induced pluripotent stem cells (iPSC) to model brain diseases is a
powerful tool for unraveling mechanistic alterations in these disorders. Rodent models of …

A high-throughput drug screen identifies potentially promising therapeutics for clinical trials.
However, limitations that persist in current disease modeling with limited physiological …

Among the disciplines of medicine, the study of neurological disorders is particularly
challenging. The fundamental inaccessibility of the human neural types affected by disease …