Understanding the mechanisms of nephron repair is critical for the design of new therapeutic
approaches to treat kidney disease. The kidney can repair after even a severe insult, but …

Ischemic injury to the kidney produces acute tubular necrosis and apoptosis followed by
tubular regeneration and recovery of renal function. Although mitotic cells are present in the …

Kidney tubular epithelium is restored without replacement with bone marrow-derived cells
during repair after ischemic injury. The kidney has the ability to restore the structural and …

Ischemia causes kidney tubular cell damage and abnormal renal function. The kidney is
capable of morphological restoration of tubules and recovery of function. Recently, it has …

Terminally differentiated cells can be reprogrammed to pluripotency or directly to another
differentiated cell type in vitro, a capacity termed cellular plasticity. Plasticity is not limited to …

A kidney is an organ with relatively low basal cellular regenerative potential. However, renal
cells have a pronounced ability to proliferate after injury, which undermines that the kidney …

Recently we have established that the kidney tubular epithelium is repaired by surviving
epithelial cells. It is not known, however, whether a population of intratubular adult …

The present study was conducted to explore renal progenitor-like cells that are actively
engaged in tubular regeneration after injury. For addressing this issue, the existence of label …

Recent studies implicated the existence in adult human kidney of a population of renal
progenitors with the potential to regenerate glomerular as well as tubular epithelial cells and …

Whether kidney proximal tubule harbors a scattered population of epithelial stem cells is a
major unsolved question. Lineage-tracing studies, histologic characterization, and ex vivo …