Current and emerging pharmacotherapy for the treatment of Lennox-Gastaut syndrome

FMC Besag, MJ Vasey, RFM Chin - Expert Opinion on …, 2023 - Taylor & Francis
ABSTRACT Introduction Lennox-Gastaut syndrome (LGS) is a severe childhood-onset
epileptic encephalopathy, characterized by multiple seizure types, generalized slow spike …

Rational approach to treatment options for Lennox‐Gastaut syndrome

GD Montouris - Epilepsia, 2011 - Wiley Online Library
Lennox‐Gastaut syndrome (LGS) is an intractable childhood‐onset epileptic
encephalopathy. Seizure freedom is rare in LGS. One of the hallmarks of LGS is medical …

[HTML][HTML] Expanding the treatment landscape for Lennox-Gastaut syndrome: current and future strategies

A Strzelczyk, S Schubert-Bast - CNS drugs, 2021 - Springer
Abstract Lennox-Gastaut syndrome (LGS), a childhood-onset severe developmental and
epileptic encephalopathy (DEE), is an entity that encompasses a heterogenous group of …

Lennox-Gastaut syndrome: management update

MH Al-Banji, DK Zahr, MM Jan - Neurosciences Journal, 2015 - nsj.org.sa
Lennox-Gastaut syndrome (LGS) is a severe pediatric epilepsy syndrome characterized by
mixed seizures, cognitive decline, and generalized slow (< 3Hz) spike wave discharges on …

Lennox-Gastaut syndrome: New treatments and treatments under investigation

S Auvin - Revue Neurologique, 2020 - Elsevier
There are currently five compounds (clobazam, felbamate, lamotrigine, topiramate,
rufinamide) available for prescription with a demonstrated efficacy on drop seizures for …

Efficacy and safety of antiseizure medication for Lennox–Gastaut syndrome: a systematic review and network meta‐analysis

L Zhang, J Wang, C Wang - Developmental Medicine & Child …, 2022 - Wiley Online Library
Aim To compare and rank the efficacy and safety of antiseizure medication (ASM) in patients
with Lennox–Gastaut syndrome (LGS). Method We included randomized controlled trials …

Pharmacotherapy of seizures associated with Lennox-Gastaut syndrome

I Borggraefe, S Noachtar - Clinical Medicine Insights …, 2010 - journals.sagepub.com
Lennox-Gastaut syndrome is an epileptic encephalopathy starting in early childhood
consisting of the triad of cognitive impairment, multiple seizures types and slow spike-wave …

Lennox-Gastaut syndrome

JW Wheless, JEC Constantinou - Pediatric neurology, 1997 - Elsevier
Lennox-Gastaut syndrome (LGS) is one of the intractable epilepsies of childhood that is
associated with an epileptic encephalopathy. Although LGS has been accepted as a distinct …

[HTML][HTML] The pharmacological management of Lennox-Gastaut syndrome and critical literature review

A Verrotti, P Striano, G Iapadre, L Zagaroli, P Bonanni… - Seizure, 2018 - Elsevier
Lennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy with a prevalence of
1–2% of all patients with epilepsy. It is characterized by multiple pharmaco-resistant seizure …

[HTML][HTML] Expert opinion on the management of Lennox–Gastaut syndrome: treatment algorithms and practical considerations

JH Cross, S Auvin, M Falip, P Striano… - Frontiers in …, 2017 - frontiersin.org
Lennox–Gastaut syndrome (LGS) is a severe epileptic and developmental encephalopathy
that is associated with a high rate of morbidity and mortality. It is characterized by multiple …