Studies on synaptic proteins involved in neurotransmitter release often aim at distinguishing
between their roles in vesicle priming (the docking of synaptic vesicles to the plasma …

Advanced imaging techniques have revealed that synapses contain nanomodules in which
pre-and post-synaptic molecules are brought together to form an integrated subsynaptic …

Glutamatergic synapses display variable strength and diverse short-term plasticity (STP),
even for a given type of connection. Using nonnegative tensor factorization and …

Chemical neurotransmission begins when synaptic vesicles fuse with the plasma membrane
at the presynaptic active zone and release their neurotransmitters. However, before synaptic …

Based on evidence that the docked and primed synaptic vesicle state is very dynamic, we
propose a three-step process for the buildup of the molecular machinery that mediates …

Synaptic vesicles (SVs) undergo multiple steps of functional maturation (priming) before
being fusion competent. We present an analysis technique, which decomposes the time …

The strength of synaptic transmission varies during trains of presynaptic action potentials,
notably because of the depletion of synaptic vesicles available for release. It has remained …

The nervous system adapts to experience by changes in synaptic strength. The mechanisms
of synaptic plasticity include changes in the probability of transmitter release and in …

How synapses change their strength in response to impinging neural activity is a
fundamental issue for understanding how the brain moulds its circuitry in response to …

The activity history of a given neuron has been suggested to influence its future responses to
synaptic input in one prominent model of experience-dependent synaptic plasticity proposed …