Differential impact of stress and environmental enrichment on corticolimbic circuits

MA Smail, BL Smith, N Nawreen, JP Herman - … biochemistry and behavior, 2020 - Elsevier
Stress exposure can produce profound changes in physiology and behavior that can impair
health and well-being. Of note, stress exposure is linked to anxiety disorders and depression …

Environmental enrichment protects against stress-induced anxiety: Role of glucocorticoid receptor, ERK, and CREB signaling in the basolateral amygdala

LS Novaes, NB Dos Santos, RFP Batalhote… - …, 2017 - Elsevier
Environmental enrichment (EE) is an experimental animal model that enhances an animal's
opportunity to interact with sensory, motor, and social stimuli, compared to standard …

Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stress

C Fox, Z Merali, C Harrison - Behavioural brain research, 2006 - Elsevier
Environmental enrichment (EE) has beneficial neurobiological, physiological and behavioral
effects. The purpose of the present paper is to review the animal research literature …

The neurogenic effects of an enriched environment and its protection against the behavioral consequences of chronic mild stress persistent after enrichment cessation …

NM Vega-Rivera, L Ortiz-López… - Behavioural Brain …, 2016 - Elsevier
Because stress may underlie the presence of depressive episodes, strategies to produce
protection against or to reverse the effects of stress on neuroplasticity and behavior are …

[HTML][HTML] Environmental enrichment increases glucocorticoid receptors and decreases GluA2 and protein kinase M zeta (PKMζ) trafficking during chronic stress: A …

RM Zanca, SH Braren, B Maloney… - Frontiers in behavioral …, 2015 - frontiersin.org
Environmental enrichment (EE) housing paradigms have long been shown beneficial for
brain function involving neural growth and activity, learning and memory capacity, and for …

[HTML][HTML] Acute stress-induced epigenetic modulations and their potential protective role toward depression

F Rusconi, E Battaglioli - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Psychiatric disorders entail maladaptive processes impairing individuals' ability to
appropriately interface with environment. Among them, depression is characterized by …

[HTML][HTML] Vascular endothelial growth factor-dependent spinogenesis underlies antidepressant-like effects of enriched environment

YF Huang, CH Yang, CC Huang, KS Hsu - Journal of Biological Chemistry, 2012 - ASBMB
Current antidepressant treatments remain limited by poor efficacy and a slow onset of action.
Increasing evidence demonstrates that enriched environment (EE) treatment can promote …

[HTML][HTML] Loss of environmental enrichment elicits behavioral and physiological dysregulation in female rats

R Morano, O Hoskins, BL Smith… - Frontiers in behavioral …, 2019 - frontiersin.org
Chronic stress drives behavioral and physiological changes associated with numerous
psychiatric disease states. In rodents, the vast majority of chronic stress models involve …

[PDF][PDF] Neural mechanisms of stress resilience and vulnerability

TB Franklin, BJ Saab, IM Mansuy - Neuron, 2012 - cell.com
Exposure to stressful events can be differently perceived by individuals and can have
persistent sequelae depending on the level of stress resilience or vulnerability of each …

[HTML][HTML] The impact of environmental factors in severe psychiatric disorders

A Schmitt, B Malchow, A Hasan, P Falkai - Frontiers in neuroscience, 2014 - frontiersin.org
During the last decades, schizophrenia has been regarded as a developmental disorder.
The neurodevelopmental hypothesis proposes schizophrenia to be related to genetic and …