[HTML][HTML] Multi-Mechanistic Approaches to the Treatment of Traumatic Brain Injury: A Review

DG Lynch, RK Narayan, C Li - Journal of Clinical Medicine, 2023 - mdpi.com
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Despite
extensive research efforts, the majority of trialed monotherapies to date have failed to …

Combination therapy for multi-target manipulation of secondary brain injury mechanisms

MR Somayaji, AJ Przekwas… - Current …, 2018 - ingentaconnect.com
Traumatic brain injury (TBI) is a major healthcare problem that affects millions of people
worldwide. Despite advances in understanding and developing preventative and treatment …

[HTML][HTML] Status of precision medicine approaches to traumatic brain injury

S Reddi, S Thakker-Varia, J Alder… - Neural Regeneration …, 2022 - journals.lww.com
Traumatic brain injury (TBI) is a serious condition in which trauma to the head causes
damage to the brain, leading to a disruption in brain function. This is a significant health …

[HTML][HTML] Emerging therapies in traumatic brain injury

PM Kochanek, TC Jackson, NM Ferguson… - Seminars in …, 2015 - thieme-connect.com
Despite decades of basic and clinical research, treatments to improve outcomes after
traumatic brain injury (TBI) are limited. However, based on the recent recognition of the …

Recent advances in the development of multifactorial therapies for the treatment of traumatic brain injury

R Vink, C Van Den Heuvel - Expert opinion on investigational …, 2004 - Taylor & Francis
Traumatic brain injury (TBI) is one of the leading causes of death and disability in the
industrialised world and remains a major health problem with serious socioeconomic …

Why does brain trauma research fail?

JL Alves, J Rato, V Silva - World Neurosurgery, 2019 - Elsevier
Traumatic brain injury (TBI) represents a major health care problem and a significant social
and economic issue worldwide. Considering the generalized failure in introducing effective …

Traumatic brain injury: future assessment tools and treatment prospects

SR Flanagan, JB Cantor, TA Ashman - … Disease and Treatment, 2008 - Taylor & Francis
Traumatic brain injury (TBI) is widespread and leads to death and disability in millions of
individuals around the world each year. Overall incidence and prevalence of TBI are likely to …

Combination therapies for traumatic brain injury: prospective considerations

S Margulies, R Hicks - Journal of neurotrauma, 2009 - liebertpub.com
Traumatic brain injury (TBI) initiates a cascade of numerous pathophysiological events that
evolve over time. Despite the complexity of TBI, research aimed at therapy development has …

Traumatic brain injury

B Aarabi, JM Simard - Current Opinion in Critical Care, 2009 - journals.lww.com
Traumatic brain injury : Current Opinion in Critical Care Traumatic brain injury : Current
Opinion in Critical Care Log in or Register Subscribe to journalSubscribe Get new issue …

[HTML][HTML] A precision medicine agenda in traumatic brain injury

J Cruz Navarro, LL Ponce Mejia… - Frontiers in …, 2022 - frontiersin.org
Traumatic brain injury remains a leading cause of death and disability across the globe.
Substantial uncertainty in outcome prediction continues to be the rule notwithstanding the …