Effect of hydrogen peroxide on lens transparency, intracellular pH, gap junction coupling, hydrostatic pressure and membrane water permeability

K Varadaraj, J Gao, RT Mathias, S Kumari - Experimental Eye Research, 2024 - Elsevier
Clouding of the eye lens or cataract is an age-related anomaly that affects middle-aged
humans. Exploration of the etiology points to a great extent to oxidative stress due to …

Lens aquaporins function as peroxiporins to facilitate membrane transport of hydrogen peroxide

K Varadaraj, SS Kumari - Biochemical and biophysical research …, 2020 - Elsevier
High levels of reactive oxygen species such as hydrogen peroxide (H 2 O 2) cause oxidative
stress in the lens and lead to cataractogenesis. The present investigation was undertaken to …

Alteration of lens electrolyte transport parameters following transient oxidative perturbation

NA Delamere, CA Paterson, DB Borchman… - Current eye …, 1988 - Taylor & Francis
Rabbit lenses were incubated, in vitro, for 20 hr. During the first 60 min of the incubation
period, the lenses were exposed to hydrogen peroxide at specified concentrations …

Ocular response to hydrogen peroxide

JR Paugh, NA Brennan, N Efron - Optometry and Vision Science, 1988 - journals.lww.com
A controlled, randomized, double-masked study was conducted on eight human subjects to
determine the threshold level of hydrogen peroxide, which is toxic when introduced into the …

Hydrogen peroxide affects specific epithelial subpopulations in cultured rabbit lenses.

JR Reddan, FJ Giblin, DC Dziedzic… - … & visual science, 1995 - iovs.arvojournals.org
PURPOSE: To investigate the effect of hydrogen peroxide on the epithelial cells of cultured
rabbit lenses. METHODS: Lenses were cultured in minimum essential medium containing a …

The effect and recovery of long-term H2O2 exposure on lens morphology and biochemistry

XL Cui, MF Lou - Experimental eye research, 1993 - Elsevier
Oxidative stress has long been speculated to play an important role in cataractogenesis. In
the H 2 O 2-induced cataract model, rat lens showed extensive biochemical damage but …

Development and characterization of an H2O2-resistant immortal lens epithelial cell line

A Spector, RR Wang, W Ma… - … ophthalmology & visual …, 2000 - iovs.arvojournals.org
purpose. To determine how nature would protect lens epithelial cells from H 2 O 2 stress, an
immortal murine lens epithelial cell line, αTN4-1, was subjected to gradually increasing H 2 …

Concentration dependent effects of hydrogen peroxide on lens epithelial cells

N Ohguro, M Fukuda, T Sasabe, Y Tano - British journal of …, 1999 - bjo.bmj.com
AIMS To evaluate the effects of hydrogen peroxide exposure on the survival and
proliferation of cultured lens epithelial cells. METHODS TOTL-86 cells, a line of rabbit lens …

Cellular injury from sustained vs. acute hydrogen peroxide exposure in cultured human corneal endothelium and human lens epithelium.

JR Polansky, DJ Fauss, T Hydorn… - The CLAO journal: official …, 1990 - europepmc.org
The duration of hydrogen peroxide (H2O2) exposure was examined in confluent monolayers
of human corneal endothelium (HCE) and human lens epithelium (HLE) by comparing 3 …

A review of the metabolism of hydrogen peroxide by external ocular structures

RL Chalmers - International Contact Lens Clinic, 1995 - Elsevier
This article reviews recent studies that measured the metabolism of hydrogen peroxide
(H2O2) by the corneal epithelium and conjunctiva. These studies on human subjects and …