The behaviour of proinsulin and insulin in the presence of zinc suggests it plays an
important role in insulin's production in the B-cell for the vast majority of animal species. The …

The results of chemical, biologic, and clinical studies of the interaction between insulin and
zinc were published in 1951 and 1952 by K. Hallas-Møller, PM Jersild, K. Petersen, and J …

In view of the known effect of zinc on the crystalline nature of insulin, we have investigated
whether zinc alters the biologic potency of this hormone. Using the rate of lipogenesis by rat …

1. The reversible interaction of zinc with pig insulin and proinsulin has been studied at pH7
by equilibrium dialysis (ultrafiltration) and by sedimentation equilibrium and velocity …

It has been shown that solutions of insulin to which approximately 0.01 per cent of zinc had
been added retained only about 40 per cent of their activity when assayed by the mouse …

IN a previous communication from these Laboratories [Scott, 1934] attention was directed to
theimportance of certain metals in the crystallisation of insulin. It was shown that zinc wasa …

In 1943 Okamoto30'31 found with the histochemical method which he had developed, that
the islets of Langerhans contain much 2inc in many animals. He stained sections of fixed …

The indispensability of zinc in the nutrition of the rat has been demonstrated in two previous
papers from this laboratory (Todd, Elvehjem and Hart, 1; Stirn, Elvehjem and Hart, 2). These …

Publisher Summary This chapter reviews the physical, chemical, and biological properties of
insulin in the light of the atomic arrangement found in insulin crystals. It also describes the …

FIG. 1. Precipitation zone of insulin (40 u/ml) in: A, 0.01 mol sodium phosphate; B, 0.01 mol
sodium phosphate with 2 mg zinc (as chloride)./1000 u; C, 0.01 mol sodium acetate; D, 0.01 …