Adenosine receptor signaling modulates permeability of the blood–brain barrier

AJ Carman, JH Mills, A Krenz, DG Kim… - Journal of …, 2011 - Soc Neuroscience
The blood–brain barrier (BBB) is comprised of specialized endothelial cells that form the
capillary microvasculature of the CNS and is essential for brain function. It also poses the …

A2A adenosine receptor regulates the human blood-brain barrier permeability

DG Kim, MS Bynoe - Molecular neurobiology, 2015 - Springer
The blood-brain barrier (BBB) symbolically represents the gateway to the central nervous
system. It is a single layer of specialized endothelial cells that coats the central nervous …

[HTML][HTML] Adenosine receptor signaling: a key to opening the blood–brain door

MS Bynoe, C Viret, A Yan, DG Kim - Fluids and Barriers of the CNS, 2015 - Springer
The aim of this review is to outline evidence that adenosine receptor (AR) activation can
modulate blood–brain barrier (BBB) permeability and the implications for disease states and …

[HTML][HTML] A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier

DG Kim, MS Bynoe - The Journal of clinical investigation, 2016 - Am Soc Clin Investig
The blood-brain barrier (BBB) protects the brain from toxic substances within the peripheral
circulation. It maintains brain homeostasis and is a hurdle for drug delivery to the CNS to …

Amyloid-β contributes to blood–brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy

AMS Hartz, B Bauer, ELB Soldner, A Wolf, S Boy… - Stroke, 2012 - Am Heart Assoc
Background and Purpose—Cerebral amyloid angiopathy (CAA) is a degenerative disorder
characterized by amyloid-β (Aβ) deposition in the blood–brain barrier (BBB). CAA …

Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier

J Keaney, DM Walsh, T O'Malley, N Hudson… - Science …, 2015 - science.org
The blood-brain barrier (BBB) is essential for maintaining brain homeostasis and protecting
neural tissue from damaging blood-borne agents. The barrier is characterized by endothelial …

[HTML][HTML] Altered brain endothelial cell phenotype from a familial Alzheimer mutation and its potential implications for amyloid clearance and drug delivery

LE Oikari, R Pandit, R Stewart, C Cuní-López, H Quek… - Stem cell reports, 2020 - cell.com
The blood-brain barrier (BBB) presents a barrier for circulating factors, but simultaneously
challenges drug delivery. How the BBB is altered in Alzheimer disease (AD) is not fully …

[HTML][HTML] The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer's disease

YL Zhang, J Wang, ZN Zhang, Q Su… - Neural regeneration …, 2022 - journals.lww.com
Neurovascular dysfunction, as an integral part of Alzheimer's disease, may have an
important influence on the onset and progression of chronic neurodegenerative processes …

Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease

AP Sagare, RD Bell… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Neurovascular dysfunction is an integral part of Alzheimer disease (AD). Changes in the
brain vascular system may contribute in a significant way to the onset and progression of …

Cytokine signaling modulates blood-brain barrier function

W Pan, KP Stone, H Hsuchou… - Current …, 2011 - ingentaconnect.com
The blood-brain barrier (BBB) provides a vast interface for cytokines to affect CNS function.
The BBB is a target for therapeutic intervention. It is essential, therefore, to understand how …