A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer's disease and gastrointestinal tract disorders

EO Adewuyi, EK O'Brien, DR Nyholt, T Porter… - Communications …, 2022 - nature.com
Consistent with the concept of the gut-brain phenomenon, observational studies suggest a
relationship between Alzheimer's disease (AD) and gastrointestinal tract (GIT) disorders; …

Shared genetic architecture between metabolic traits and Alzheimer's disease: a large-scale genome-wide cross-trait analysis

Z Zhu, Y Lin, X Li, JA Driver, L Liang - Human genetics, 2019 - Springer
A growing number of studies clearly demonstrate a substantial link between metabolic
dysfunction and the risk of Alzheimer's disease (AD), especially glucose-related dysfunction; …

The complex genetic architecture of Alzheimer's disease: novel insights and future directions

SJ Andrews, AE Renton, B Fulton-Howard… - …, 2023 - thelancet.com
Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …

Understanding Alzheimer disease at the interface between genetics and transcriptomics

J Verheijen, K Sleegers - Trends in Genetics, 2018 - cell.com
Over 25 genes are known to affect the risk of developing Alzheimer disease (AD), the most
common neurodegenerative dementia. However, mechanistic insights and improved …

Genome-wide pathway analysis of memory impairment in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort implicates gene candidates, canonical …

VK Ramanan, S Kim, K Holohan, L Shen, K Nho… - Brain imaging and …, 2012 - Springer
Memory deficits are prominent features of mild cognitive impairment (MCI) and Alzheimer's
disease (AD). The genetic architecture underlying these memory deficits likely involves the …

Investigating casual associations among gut microbiota, metabolites, and neurodegenerative diseases: a Mendelian randomization study

J Ning, SY Huang, SD Chen, YR Zhang… - Journal of …, 2022 - content.iospress.com
Background: Recent studies had explored that gut microbiota was associated with
neurodegenerative diseases (including Alzheimer's disease (AD), Parkinson's disease (PD) …

Genetic correlations between Alzheimer's disease and gut microbiome genera

D Cammann, Y Lu, MJ Cummings, ML Zhang… - Scientific Reports, 2023 - nature.com
A growing body of evidence suggests that dysbiosis of the human gut microbiota is
associated with neurodegenerative diseases like Alzheimer's disease (AD) via …

Role of the gut-brain axis in the shared genetic etiology between gastrointestinal tract diseases and psychiatric disorders: A genome-wide pleiotropic analysis

W Gong, P Guo, Y Li, L Liu, R Yan, S Liu… - JAMA …, 2023 - jamanetwork.com
Importance Comorbidities and genetic correlations between gastrointestinal tract diseases
and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) …

Towards understanding brain-gut-microbiome connections in Alzheimer's disease

R Xu, QQ Wang - BMC systems biology, 2016 - Springer
Background Alzheimer's disease (AD) is complex, with genetic, epigenetic, and
environmental factors contributing to disease susceptibility and progression. While …

Are neurodegenerative diseases associated with an increased risk of inflammatory bowel disease? A two-sample Mendelian randomization study

G Cui, S Li, H Ye, Y Yang, Q Huang, Y Chu… - Frontiers in …, 2022 - frontiersin.org
Background Several studies have shown that neurodegenerative diseases (eg, Parkinson's
disease [PD] and Alzheimer's disease [AD]) are associated with inflammatory bowel disease …