Leishmaniasis is an infectious disease complex caused by protozoa from the Leishmania
genus, which presents a broad spectrum of clinical manifestations: cutaneous …

The main form of control of leishmaniasis is the treatment, however various side effects and
poor efficacy are associated with presently available drugs. The investigation of bioactive …

Background Leishmaniasis is a disease caused by the protozoan parasite, Leishmania. The
disease remains a global threat to public health requiring effective chemotherapy for control …

This study focuses on the in vitro antileishmanial evaluation of twenty original flavones
which differ in substituent of the A-ring, mainly at C-7, and in substitution pattern of the lateral …

Seven benzo [c] phenanthridines, synthetic or isolated from Zanthoxylum rhoifolium root
bark, were evaluated against Leishmania amazonensis axenic amastigotes. Five of them …

Treatment of leishmaniasis by chemotherapy remains a challenge because of limited
efficacy, toxic side effects, and drug resistance. We previously reported that synthetic …

Leishmaniasis is a group of infectious-parasitic diseases with high mortality rates, and
endemic in many regions of the globe. The currently available drugs present serious …

Leishmaniasis has become a significant public health issue in several countries in the world.
New products have been identified to treat against the disease; however, toxicity and/or high …

Context: Leishmaniasis is a widespread tropical infection caused by different species of
Leishmania protozoa. There is no immunoprophylaxis (vaccination) available for …

Despite recent advances in the treatment of some forms of leishmaniasis, the available
drugs are still far from ideal due to inefficacy, parasite resistance, toxicity and cost. The wide …