A clinical perspective of the multifaceted mechanism of metformin in diabetes, infections, cognitive dysfunction, and cancer

E Chow, A Yang, CHL Chung, JCN Chan - Pharmaceuticals, 2022 - mdpi.com
In type 2 diabetes, ecological and lifecourse factors may interact with the host microbiota to
influence expression of his/her genomes causing perturbation of interconnecting biological …

Metformin: From Diabetes to Cancer—Unveiling Molecular Mechanisms and Therapeutic Strategies

E Amengual-Cladera, PM Morla-Barcelo… - Biology, 2024 - mdpi.com
Simple Summary Metformin, a common anti-diabetic drug, is being explored for its potential
in managing cancer, especially in breast and colorectal cancer. It works by affecting …

Molecular mechanisms of metformin for diabetes and cancer treatment

M Li, X Li, H Zhang, Y Lu - Frontiers in physiology, 2018 - frontiersin.org
Metformin has been the first-line drug treatment for hyperglycemia and insulin resistance for
over 50 years. However, the molecular basis of its therapeutic role remained incompletely …

A story of metformin-butyrate synergism to control various pathological conditions as a consequence of gut microbiome modification: Genesis of a wonder drug?

K Maniar, A Moideen, A Mittal, A Patil… - Pharmacological …, 2017 - Elsevier
The most widely prescribed oral anti-diabetic agent today in the world today is a member of
the biguanide class of drugs called metformin. Apart from its use in diabetes, it is currently …

Metformin: A Dual-Role Player in Cancer Treatment and Prevention

MA Galal, M Al-Rimawi, A Hajeer, H Dahman… - International Journal of …, 2024 - mdpi.com
Cancer continues to pose a significant global health challenge, as evidenced by the
increasing incidence rates and high mortality rates, despite the advancements made in …

Metformin: on ongoing journey across diabetes, cancer therapy and prevention

C Pulito, T Sanli, P Rana, P Muti, G Blandino, S Strano - Metabolites, 2013 - mdpi.com
Cancer metabolism is the focus of intense research, which witnesses its key role in human
tumors. Diabetic patients treated with metformin exhibit a reduced incidence of cancer and …

Targeting ageing and preventing organ degeneration with metformin

AP Sunjaya, AF Sunjaya - Diabetes & Metabolism, 2021 - Elsevier
Background Ageing is characterized by a decline in cognitive and bodily functions.
Metformin, the most commonly prescribed antidiabetic agent today, has proved to be able to …

Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing

Y Hua, Y Zheng, Y Yao, R Jia, S Ge… - Journal of Translational …, 2023 - Springer
Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging
applications, including as an anti-cancer agent. It boasts the distinct advantages of an …

Metformin: A review of potential mechanism and therapeutic utility beyond diabetes

S Dutta, RB Shah, S Singhal, SB Dutta… - Drug Design …, 2023 - Taylor & Francis
Metformin has been designated as one of the most crucial first-line therapeutic agents in the
management of type 2 diabetes mellitus. Primarily being an antihyperglycemic agent …

Amelioration of metabolic syndrome by metformin associates with reduced indices of low-grade inflammation independently of the gut microbiota

A Adeshirlarijaney, J Zou, HQ Tran… - American Journal …, 2019 - journals.physiology.org
Metformin beneficially impacts several aspects of metabolic syndrome including
dysglycemia, obesity, and liver dysfunction, thus making it a widely used frontline treatment …