APOL1 Induces Pyroptosis of Fibroblasts Through NLRP3/Caspase-1/GSDMD Signaling Pathway in Ulcerative Colitis

F Zhu, S Li, Q Gu, N Xie, Y Wu - Journal of Inflammation Research, 2023 - Taylor & Francis
Background Pyroptosis is a form of proinfammatory gasdermin-mediated programmed cell
death. Abnormal infammation in the intestine is a critical risk factor for Ulcerative colitis (UC) …

[HTML][HTML] Identification and exploration of pharmacological pyroptosis-related biomarkers of ulcerative colitis

K Chen, S Shang, S Yu, L Cui, S Li, N He - Frontiers in Immunology, 2022 - frontiersin.org
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD). Its etiology is unclear.
Much evidence suggests that the death of abnormal intestinal epithelial cells (IECs) leads to …

Exploring Pyroptosis-related Signature Genes and Potential Drugs in Ulcerative Colitis by Transcriptome Data and Animal Experimental Validation

Y Zhao, Y Ma, J Pei, X Zhao, Y Jiang, Q Liu - Inflammation, 2024 - Springer
Ulcerative colitis (UC) is an idiopathic, relapsing inflammatory disorder of the colonic
mucosa. Pyroptosis contributes significantly to UC. However, the molecular mechanisms of …

Pyroptosis‐Related Signature Predicts the Progression of Ulcerative Colitis and Colitis‐Associated Colorectal Cancer as well as the Anti‐TNF Therapeutic Response

Y Ning, K Lin, J Fang, X Chen, X Hu… - Journal of …, 2023 - Wiley Online Library
Ulcerative colitis (UC) is a complex intestinal inflammation with an increasing risk of colitis‐
associated colorectal cancer (CAC). However, the pathogenesis is still unclear between …

[引用][C] Adenosine A3 Receptor Interacts With Gasdermin D To Modulate Intestinal Epithelial Cell Pyroptosis in Ulcerative Colitis

P Xiao, M Lv, W Chen, T Tian, T Ren - Gastroenterology, 2021 - gastrojournal.org
Background Adenosine A3 receptor (A3AR) plays a role in intestinal inflammation, but little
is known about its mechnisms in intestinal inflammation such as ulcerative colitis (UC) …

Lipocalin-2-mediated intestinal epithelial cells pyroptosis via NF-κB/NLRP3/GSDMD signaling axis adversely affects inflammation in colitis

Y Yang, S Li, K Liu, Y Zhang, F Zhu, T Ben… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Ulcerative colitis (UC) is a major inflammatory bowel disease (IBD) characterized by
intestinal epithelium damage. Recently, Lipocalin-2 (LCN2) has been identified as a …

[HTML][HTML] Gα12 and endoplasmic reticulum stress-mediated pyroptosis in a single cycle of dextran sulfate-induced mouse colitis

J Tak, Q An, SG Lee, CH Lee, SG Kim - Scientific Reports, 2024 - nature.com
Inflammatory bowel disease (IBD) pathogenesis involves complex inflammatory events and
cell death. Although IBD involves mainly necrosis in the digestive tract, pyroptosis has also …

KLF4 interacts with TXNIP to modulate the pyroptosis in ulcerative colitis via regulating NLRP3 signaling

Y Chen, L Sun, H Liu, J Li, L Guo… - Immunity, Inflammation …, 2024 - Wiley Online Library
Introduction Ulcerative colitis (UC) is one of the most common diseases in the
gastrointestinal tract related to abnormal inflammation. Pyroptosis, which is characterized by …

[HTML][HTML] Analysis of cuproptosis-related genes in Ulcerative colitis and immunological characterization based on machine learning

Z Wang, Y Wang, J Yan, Y Wei, Y Zhang… - Frontiers in …, 2023 - frontiersin.org
Cuproptosis is a novel form of cell death, mediated by protein lipid acylation and highly
associated with mitochondrial metabolism, which is regulated in the cell. Ulcerative colitis …

[PDF][PDF] A narrative review of pyrolysis and its role in ulcerative colitis.

J Li, CM Ma, DL Di - European Review for Medical & …, 2022 - europeanreview.org
Cell death is one of the inevitable life activities of cells during the growth and development of
the body. Regulated cell death (RCD) is a type of cell death mode that can be regulated and …