Acetylcholinesterase (AChE) predominates in the healthy brain, with butyrylcholinesterase
(BuChE) considered to play a minor role in regulating brain acetylcholine (ACh) levels …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the elderly,
characterised by widespread loss central cholinergic function. The only symptomatic …

Objective: To examine the role of butyrylcholinesterase (BuChE) in cholinergic signaling and
neurologic conditions, such as Alzheimer's disease (AD). The rationale for inhibiting …

Cholinesterase inhibitors are the standard of care for Alzheimer's disease (AD).
Acetylcholinesterase (AChE) catalyzes the hydrolysis of the cholinergic neurotransmitter …

The brain of mammals contains two major forms of cholinesterases (ChEs):
acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The two forms differ …

Abstract The cholinesterase inhibitors (ChE-Is) attenuate the cholinergic deficit underlying
the cognitive and neuropsychiatric dysfunctions in patients with AD. Inhibition of brain …

Butyrylcholinesterase is a serine hydrolase biochemically related to the cholinergic enzyme
acetylcholinesterase. It is capable of hydrolyzing esters of choline. Butyrylcholinesterase has …

The serine hydrolase butyrylcholinesterase (BChE), like the related enzyme
acetylcholinesterase (AChE), co-regulates metabolism of the neurotransmitter acetylcholine …

Since degenerative alterations associated with cholinergic changes in the brains of
demented patients occur in specific regions, optimal efficacy may be achieved by targeting …

Alzheimer's disease (AD) is characterized by severe basal forebrain cholinergic deficit,
which results in progressive and chronic deterioration of memory and cognitive functions …