Amyloid protein is well known to induce neuronal cell death, whereas only little is known
about its effect on astrocytes. We found that amyloid peptides activated caspase 3 and …

Amyloid-β (Aβ) associates with extracellular vesicles termed exosomes. It is not clear
whether and how exosomes modulate Aβ neurotoxicity in Alzheimer's disease (AD). We …

Amyloid-β peptide (Aβ) accumulation in senile plaques, a pathological hallmark of
Alzheimer's disease (AD), has been implicated in neuronal degeneration. We have recently …

Accumulating evidences indicate that ceramide is closely involved in apoptotic cell death in
neurodegenerative disorders and aging. We examined ceramide levels in the cerebrospinal …

Alzheimer's disease (AD), the most common chronic and progressive neurodegenerative
disorder, is characterized by extracellular deposits of amyloid β‐peptides (Aβ) and …

We present evidence here that exosomes stimulate aggregation of amyloid beta (Aβ) 1− 42
in vitro and in vivo and interfere with uptake of Aβ by primary cultured astrocytes and …

Th1 pro-inflammatory cytokines, ie, TNF-α and IFN-γ, in combination are known to induce
cell death in several cell types, including oligodendrocytes, but the mechanism of their …

Recent evidence implicates exosomes in the aggregation of Aβ and spreading of tau in
Alzheimer9s disease. In neural cells, exosome formation can be blocked by inhibition or …

Mechanisms of neuronal loss in Alzheimer's disease (AD) are poorly understood. Here we
show that apoptosis is a major form of neuronal cell death in PS/APP mice modeling AD-like …

Amyloid β-peptide (Aβ), the pathogenic agent of Alzheimer disease, is a physiological
metabolite whose levels are constantly controlled in normal brain. Recent studies have …