HAMLET in human milk is resistant to digestion and carries essential free long chain polyunsaturated fatty acids and oleic acid
The oleic acid/alpha-lactalbumin complex HAMLET (human alpha-lactalbumin made lethal
to tumors) is cytotoxic to various cancerous cell lines and is assembled from alpha …
to tumors) is cytotoxic to various cancerous cell lines and is assembled from alpha …
The formation of an anti-cancer complex under simulated gastric conditions
A potent anti-cancer complex has previously been formed from two major components of
milk. Human/bovine α-lactalbumin made lethal to tumour cells (H/BAMLET) is a protein–fatty …
milk. Human/bovine α-lactalbumin made lethal to tumour cells (H/BAMLET) is a protein–fatty …
α-Lactalbumin, engineered to be nonnative and inactive, kills tumor cells when in complex with oleic acid: a new biological function resulting from partial unfolding
J Pettersson-Kastberg, AK Mossberg… - Journal of molecular …, 2009 - Elsevier
HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a tumoricidal complex
consisting of partially unfolded protein and fatty acid and was first identified in casein …
consisting of partially unfolded protein and fatty acid and was first identified in casein …
Structure and function of human α‐lactalbumin made lethal to tumor cells (HAMLET)‐type complexes
AK Mossberg, K Hun Mok… - The FEBS …, 2010 - Wiley Online Library
Human α‐lactalbumin made lethal to tumor cells (HAMLET) and equine lysozyme with oleic
acid (ELOA) are complexes consisting of protein and fatty acid that exhibit cytotoxic …
acid (ELOA) are complexes consisting of protein and fatty acid that exhibit cytotoxic …
[HTML][HTML] Compact oleic acid in HAMLET
HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a complex between α-
lactalbumin and oleic acid that induces apoptosis in tumor cells, but not in healthy cells …
lactalbumin and oleic acid that induces apoptosis in tumor cells, but not in healthy cells …
Heat-treatment method for producing fatty acid-bound alpha-lactalbumin that induces tumor cell death
T Kamijima, A Ohmura, T Sato, K Akimoto… - Biochemical and …, 2008 - Elsevier
HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells), which was identified in
human breast milk as an alpha-lactalbumin (LA)–oleic acid complex, kills tumor cells …
human breast milk as an alpha-lactalbumin (LA)–oleic acid complex, kills tumor cells …
Cytotoxic lactalbumin-oleic acid complexes in the human milk diet of preterm infants
Frozen storage is necessary to preserve expressed human milk for critically ill and very
preterm infants. Milk pasteurization is essential for donor milk given to this special …
preterm infants. Milk pasteurization is essential for donor milk given to this special …
α-Lactalbumin species variation, HAMLET formation, and tumor cell death
J Pettersson, AK Mossberg, C Svanborg - Biochemical and biophysical …, 2006 - Elsevier
HAMLET (human α-lactalbumin made lethal to tumor cells) is a tumoricidal complex of apo α-
lactalbumin and oleic acid, formed in casein after low pH treatment of human milk. This study …
lactalbumin and oleic acid, formed in casein after low pH treatment of human milk. This study …
[PDF][PDF] HAMLET, protein folding, and tumor cell death
KH Mok, J Pettersson, S Orrenius… - … and biophysical research …, 2007 - cohensw.com
HAMLET (Human a-lactalbumin made lethal to tumor cells) was discovered by serendipity.
The first publication in 1995 described the discovery and the unusual properties of what later …
The first publication in 1995 described the discovery and the unusual properties of what later …
Binding of α-lactalbumin to oleic acid monolayer and its relevance to formation of HAMLET-like complexes
K Dopierała, M Krajewska, K Prochaska - International Dairy Journal, 2019 - Elsevier
The α-lactalbumin from human milk forms a cytotoxic protein-fatty acid complex with oleic
acid (OA) called HAMLET, which is probably formed in the stomach of a breastfed infant …
acid (OA) called HAMLET, which is probably formed in the stomach of a breastfed infant …