A fascinating link between sterols and molecular oxygen (O2) has been a common thread
running through the fundamental work of Konrad Bloch, who elucidated the biosynthetic …

Although often considered in a negative light, cholesterol is an essential molecule with
unusually diverse functions. Cholesterol and related sterols (ergosterol in yeast, phytosterols …

It has been widely accepted that there exists a correlation between prokaryotes-to-
eukaryotes evolution and atmospheric oxygen rise. However, it is a great challenge to …

Oxysterols are the 27-carbon products of cholesterol oxidation by both enzymic and non-
enzymic mechanisms. Their roles in cholesterol homeostasis, as well as in diseases in …

The question is rarely asked, why is it that only certain chemical structures and not others
are present in living systems? Or, put differently, can we rationalize the detailed design and …

Oxysterols are structurally identical to cholesterol, but with one or more additional oxygen
containing functional groups (such as alcohol, carbonyl or epoxide groups). The wide array …

Oxysterols are critical regulators of inflammation and cholesterol metabolism in cells. They
are oxidation products of cholesterol and may be differentially metabolised in subcellular …

The main biological cause of oxysterols is the oxidation of cholesterol. They differ from
cholesterol by the presence of additional polar groups that are typically hydroxyl, keto …

Tight regulation of cellular and plasma cholesterol is crucial to proper cellular functioning
because excess free cholesterol is toxic to cells and is associated with atherosclerosis and …

Oxysterols are oxygenated forms of cholesterol generated via autooxidation by free radicals
and ROS, or formed enzymically by a variety of enzymes such as those involved in the …