Endothelial cells exert an enormous influence on blood vessels throughout the circulation,
but their impact is particularly pronounced in the brain. New concepts have emerged …

Current theories state that Alzheimer's disease (AD) is a vascular disorder that initiates its
pathology through cerebral microvascular abnormalities. Endothelial dysfunction caused by …

While numerous lines of evidence point to increased levels of oxidative stress playing a
causal role in a number of neurodegenerative conditions, our current understanding of the …

The consequences of cerebrovascular disease are among the leading health issues
worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the …

The blood vessels of the brain are lined with endothelial cells and it has been long known
that these help to regulate blood flow to the brain. However, there is increasing evidence …

There is a complex interaction between the brain and the cerebral vasculature to meet the
metabolic demands of the brain for proper function. Preservation of cerebrovascular function …

Apart from the cardiovascular system, several cerebrovascular defense mechanisms
inherently function to maintain homeostasis of the neurovascular unit. Prevailing evidence …

Maintenance of brain function depends on a constant blood supply. Deficits in cerebral
blood flow are linked to cognitive decline, and they have detrimental effects on the outcome …

Alzheimer's disease (AD) is characterized by a progressive decline of cognitive functions
and represents the most common form of dementia and a major cause of morbidity and …

Aging, Alzheimer disease, and hypertension, major determinants of cognitive dysfunction,
are associated with profound alterations in the structure and function of cerebral blood …