Intermittent hypoxia induces hyperlipidemia in lean mice

J Li, LN Thorne, NM Punjabi, CK Sun… - Circulation …, 2005 - Am Heart Assoc
Obstructive sleep apnea, a syndrome leading to recurrent intermittent hypoxia (IH), has been
associated previously with hypercholesterolemia, independent of underlying obesity. We …

Chronic intermittent hypoxia upregulates genes of lipid biosynthesis in obese mice

J Li, DN Grigoryev, SQ Ye, L Thorne… - Journal of Applied …, 2005 - journals.physiology.org
Obstructive sleep apnea (OSA), a condition tightly linked to obesity, leads to chronic
intermittent hypoxia (CIH) during sleep. There is emerging evidence that OSA is …

Chronic intermittent hypoxia induces atherosclerosis

V Savransky, A Nanayakkara, J Li… - American journal of …, 2007 - atsjournals.org
Rationale: Obstructive sleep apnea, a condition leading to chronic intermittent hypoxia
(CIH), is associated with hyperlipidemia, atherosclerosis, and a high cardiovascular risk. A …

Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia

J Li, V Savransky, A Nanayakkara… - Journal of applied …, 2007 - journals.physiology.org
Obstructive sleep apnea (OSA) is characterized by chronic intermittent hypoxia (CIH) and
associated with dysregulation of lipid metabolisms and atherosclerosis. Causal relationships …

Acute hypoxia induces hypertriglyceridemia by decreasing plasma triglyceride clearance in mice

JC Jun, MK Shin, Q Yao… - American Journal …, 2012 - journals.physiology.org
Obstructive sleep apnea (OSA) induces intermittent hypoxia (IH) during sleep and is
associated with elevated triglycerides (TG). We previously demonstrated that mice exposed …

Metabolic consequences of intermittent hypoxia: relevance to obstructive sleep apnea

LF Drager, JC Jun, VY Polotsky - Best practice & research Clinical …, 2010 - Elsevier
Obstructive sleep apnea (OSA) is recurrent obstruction of the upper airway leading to sleep
fragmentation and intermittent hypoxia (IH) during sleep. There is growing evidence from …

Intermittent hypoxia increases insulin resistance in genetically obese mice

VY Polotsky, J Li, NM Punjabi, AE Rubin… - The Journal of …, 2003 - Wiley Online Library
Obstructive sleep apnoea, a syndrome that leads to recurrent intermittent hypoxia, is
associated with insulin resistance in obese individuals, but the mechanisms underlying this …

Inflammation contributes to the atherogenic role of intermittent hypoxia in apolipoprotein-E knock out mice

C Arnaud, L Poulain, P Lévy, M Dematteis - Atherosclerosis, 2011 - Elsevier
RATIONALE: Obstructive sleep apnea results in nocturnal intermittent hypoxia (IH) as a main
trigger for cardiovascular morbidity, including atherosclerosis. IH induces hemodynamic …

Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient mice

J Jun, C Reinke, D Bedja, D Berkowitz, S Bevans-Fonti… - Atherosclerosis, 2010 - Elsevier
OBJECTIVE: Obstructive sleep apnea causes intermittent hypoxia (IH) and is associated
with increased cardiovascular mortality. This increased risk may be attributable to more …

Intermittent hypoxia exacerbates metabolic effects of diet‐induced obesity

LF Drager, J Li, C Reinke, S Bevans‐Fonti, JC Jun… - …, 2011 - Wiley Online Library
Obesity causes insulin resistance (IR) and nonalcoholic fatty liver disease (NAFLD), but the
relative contribution of sleep apnea is debatable. The main aim of this study is to evaluate …