Regulation of the volume and electrolyte composition of the cerebrospinal fluid (CSF) is vital
for brain development and function. The Na-K-Cl co-transporter NKCC1 in the choroid …

Cerebrospinal fluid (CSF) provides vital support for the brain. Abnormal CSF accumulation,
such as hydrocephalus, can negatively affect perinatal neurodevelopment. The mechanisms …

Choroid plexus epithelial cells (CPECs) secrete cerebrospinal fluid (CSF) and regulate its
electrolyte composition. CPECs express Na+/K+ ATPase and Na+‐K+‐2Cl− cotransporter 1 …

Cerebrospinal fluid (CSF) is crucial for normal function and mechanical protection of the
CNS. The choroid plexus epithelium (CPe) is primarily responsible for secreting CSF and …

Cerebrospinal fluid (CSF) production occurs at a rate of 500 ml per day in the adult human.
Conventional osmotic forces do not suffice to support such production rate and the …

The choroid plexus is a small monolayered epithelium located in the brain ventricles and
serves to secrete the cerebrospinal fluid (CSF) that envelops the brain and fills the central …

Disturbances in the brain fluid balance can lead to life-threatening elevation in the
intracranial pressure (ICP), which represents a vast clinical challenge. Nevertheless, the …

NKCC1 is a broadly expressed Na+–K+–Cl− co‐transporter involved in regulation of ion flux
across the cell membrane and in regulating cell volume. Whilst much is known about the co …

Therapeutic agents that restore the inhibitory actions of γ-amino butyric acid (GABA) by
modulating intracellular chloride concentrations will provide novel avenues to treat stroke …

Abstract The electroneutral Na–K–Cl co–transporter (NKCC) protein transports Na+, K+ and
Cl− into cells under physiological conditions with a stoichiometry of 1Na+: 1K+: 2Cl−. NKCC …