Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …

There is increasing evidence for the involvement of mitochondrial dysfunction and oxidative
stress in the pathogenesis of many of the major neurodegenerative and neuroinflammatory …

Neuromuscular disorders with defects in the mitochondrial ATP-generating system affect a
large number of children and adults worldwide, but remain without treatment. We used a …

Mitochondria play a key role in energy production, calcium homeostasis, cell survival, and
death. Adverse stimulations including neurodegenerative diseases may result in …

The constant high energy demand of neurons makes them rely heavily on their
mitochondria. Dysfunction of mitochondrial energy metabolism leads to reduced ATP …

Neurons are specialized cells with unique features, including a constant high demand for
energy. Mitochondria satisfy this constant demand, and are emerging as a central target for …

Recently, growing evidence has demonstrated that peroxisome proliferator activated
receptor γ (PPARγ) coactivator-1α (PGC-1α) is a superior transcriptional regulator that acts …

Parkinson's disease (PD) is a progressive and chronic neurodegenerative disorder,
characterized by progressive loss of dopaminergic neurons in substantia nigra. The etiology …

The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated
transcriptional factor that belongs to the nuclear hormone receptor superfamily. PPARγ was …

Neurodegenerative disorders (NDDs) are characterized by progressive loss of selectively
vulnerable neuronal populations and myelin sheath, leading to behavioral and cognitive …