Constitutive nuclear factor-κB activity is required for central neuron survival

AL Bhakar, LL Tannis, C Zeindler… - Journal of …, 2002 - Soc Neuroscience
The function of nuclear factor (NF)-κB within the developing and mature CNS is
controversial. We have generated transgenic mice to reveal NF-κB transcriptional activity in …

Minimal NF-κB activity in neurons

SJ Listwak, P Rathore, M Herkenham - Neuroscience, 2013 - Elsevier
Nuclear factor-kappa B (NF-κB) is a ubiquitous transcription factor that regulates immune
and cell-survival signaling pathways. NF-κB has been reported to be present in neurons …

NF‐kappaB dimers in the regulation of neuronal survival

I Sarnico, A Lanzillotta, M Benarese, M Alghisi… - International review of …, 2009 - Elsevier
Nuclear factor‐kappaB (NF‐κB) is a dimeric transcription factor composed of five members,
p50, RelA/p65, c‐Rel, RelB, and p52 that can diversely combine to form the active …

NF-κB functions in the nervous system: from development to disease

S Mémet - Biochemical pharmacology, 2006 - Elsevier
The transcription factor nuclear factor-κB (NF-κB) is an ubiquitously expressed dimeric
molecule with post-translationally regulated activity. Its role in the immune system and host …

Roles for NF-κB in nerve cell survival, plasticity, and disease

MP Mattson, MK Meffert - Cell Death & Differentiation, 2006 - nature.com
Here we review evidence of roles for NF-κB in the regulation of developmental and synaptic
plasticity, and cell survival in physiological and pathological settings. Signaling pathways …

Roles of nuclear factor κB in neuronal survival and plasticity

MP Mattson, C Culmsee, ZF Yu… - Journal of …, 2000 - Wiley Online Library
The transcription factor nuclear factor κB (NF‐κB) is moving to the forefront of the fields of
apoptosis and neuronal plasticity because of recent findings showing that activation of NF …

NF-κB in the nervous system

B Kaltschmidt, C Kaltschmidt - Cold Spring Harbor …, 2009 - cshperspectives.cshlp.org
The transcription factor NF-κB has diverse functions in the nervous system, depending on
the cellular context. NF-κB is constitutively activated in glutamatergic neurons. Knockout of …

NF-κB signaling pathways: role in nervous system physiology and pathology

S Mincheva-Tasheva, RM Soler - The Neuroscientist, 2013 - journals.sagepub.com
Intracellular pathways related to cell survival regulate neuronal physiology during
development and neurodegenerative disorders. One of the pathways that have recently …

Opposing roles for NF-κB/Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-1β

M Pizzi, F Goffi, F Boroni, M Benarese… - Journal of Biological …, 2002 - ASBMB
The nuclear transcription factors NF-κB/Rel have been shown to function as key regulators
of either cell death or survival in neuronal cells. Here, we investigated whether selective …

NF-κB in the survival and plasticity of neurons

MP Mattson - Neurochemical research, 2005 - Springer
The transcription factor nuclear factor kappa-B (NF-κB) is involved in regulating responses of
neurons to activation of several different signaling pathways in a variety of physiological and …