Bicarbonate facilitates mucin unpacking and bacterial killing; however, its transport
mechanisms in the airways are not well understood. cAMP stimulates anion efflux through …

Bicarbonate plays an important role in airway host defense, however, its transport
mechanisms remain uncertain. Here we examined the relative contributions of the anion …

In most HCO 3−-secreting epithelial tissues, SLC26 Cl−/HCO 3− transporters work in concert
with the cystic fibrosis transmembrane conductance regulator (CFTR) to regulate the …

The transport of chloride and bicarbonate across epithelia controls the pH and volume of the
intracellular and luminal fluids, as well as the systemic pH and vascular volume. The anion …

Abstract Pendrin (SLC26A4) is a Cl−/anion exchanger expressed in the epithelium of
inflamed airways where it is thought to facilitate Cl− absorption and HCO 3− secretion …

Pendrin is an anion exchanger whose mutations are known to cause hearing loss. However,
recent data support the linkage between pendrin expression and airway diseases, such as …

Bicarbonate secretion is a fundamental process involved in maintaining acid-base
homeostasis. Disruption of bicarbonate entry into airway lumen, as has been observed in …

The pH of airway surface liquid (ASL) is a key factor that determines respiratory host
defense; ASL acidification impairs and alkalinization enhances key defense mechanisms …

Aberrant anion secretion across the bronchial epithelium is associated with airway disease,
most notably in cystic fibrosis. Although the cystic fibrosis transmembrane conductance …

The expression and function of the anion exchanger pendrin (SLC26A4) was thought to be
limited mainly to the inner ear, kidney and thyroid. Recent data indicates that pendrin is also …