Emerging evidence points to a strong association between the gut microbiota and the risk,
development and progression of gastrointestinal cancers such as colorectal cancer (CRC) …

The prevalence of colorectal cancer (CRC) has markedly increased worldwide in the last
decade. Alterations of bile acid metabolism and gut microbiota have been reported to play …

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a
leading cause of cancer-related deaths globally, with few effective therapeutic options. Bile …

Despite decades of bile acid research, diverse biological roles for bile acids have been
discovered recently due to developments in understanding the human microbiota. As …

Bile acids have emerged as important signaling molecules in the host, as they interact either
locally or systemically with specific cellular receptors, in particular the farnesoid X receptor …

In a recent excellent Review 1 (Bile acid–microbiota crosstalk in gastrointestinal
inflammation and carcinogenesis. Nat. Rev. Gastroenterol. Hepatol. 15, 111–128 (2018)) …

The composition of the bile acid pool is a function of the microbial metabolism of bile acids in
the intestine. Perturbations of the microbiota shape the bile acid pool and modulate the …

The intensive crosstalk between the liver and the intestine performs many essential
functions. This crosstalk is important for natural immune surveillance, adaptive immune …

The human gastrointestinal tract is colonized by a complex and dynamic range of symbiotic
microorganisms, collectively termed the gut microbiome, which defends the human host …

The understanding of the complex role of the bile acid-gut microbiome axis in health and
disease processes is evolving rapidly. Our focus revolves around the interaction of the gut …