Butyrylcholinesterase (BChE) plays an important role in the progression of the Alzheimer's
disease. In this study, we used a structure-based virtual screening (VS) approach to discover …

As there are increased levels and activity of butyrylcholiesterase (BChE) in the late stage of
Alzheimer's disease (AD), development of selective BChE inhibitors is of vital importance. In …

Butyrylcholinesterase (BChE) is recently considered as a new target for the treatment of
Alzheimer's disease (AD). There is an increasing interest in the development of BChE …

In this study, a series of selective butyrylcholinesterase (BChE) inhibitors was designed and
synthesized from the structural optimization of hit 1, a 4-((3, 4-dihydroisoquinolin-2 (1 H)-yl) …

Cholinesterase inhibitors have long been used in the treatment of Alzheimer's Disease (AD)
via the protection of acetylcholine levels. However, recent research has shown that the …

Butyrylcholinesterase (BChE) is regarded as a promising drug target as its levels and activity
significantly increase in the late stages of Alzheimer's disease. To discover novel BChE …

Butyrylcholinesterase (BChE) is a nonspecific cholinesterase enzyme that hydrolyzes
choline-based esters. BChE plays a critical role in maintaining normal cholinergic function …

For the potential therapy of Alzheimer's disease (AD), butyrylcholinesterase (BChE) has
gradually gained worldwide interest in the progression of AD. This study used a …

Alzheimer's disease (AD) is the most common type of age-related dementia. Inhibition of
butyrylcholinesterase (BChE) emerge as an effective therapeutic target for AD. A series of …

Structure-based virtual screening of two libraries containing 567 981 molecules was used to
discover novel, selective BuChE inhibitors, which are potentially superior symptomatic …