Effects of bupropion on sign-and goal-tracking in male Sprague Dawley rats

JM Holden - Behavioural Brain Research, 2023 - Elsevier
Relapse into addiction is often triggered by cues that have a Pavlovian association with
drugs and drug-taking. Sign-tracking involves approach of and interaction with Pavlovian …

Dextromethorphan reduces sign-tracking but not goal-tracking in male Sprague-Dawley rats

JM Holden, A Salem - Neurobiology of Learning and Memory, 2022 - Elsevier
Sign-tracking is a well-known phenomenon in appetitive Pavlovian conditioning in which
subjects approach the site of a conditioned stimulus (CS) associated with an appetitive …

Effects of three serotonin reuptake inhibitors on sign-tracking in male Sprague-Dawley rats

JM Holden - Physiology & Behavior, 2023 - Elsevier
Sign-tracking is a behavior with relevance to cue-triggered relapse addiction, a Pavlovian
conditioned approach behavior directed at the conditioned stimulus. The study examined …

Bupropion differentially impacts acquisition of methamphetamine self-administration and sucrose-maintained behavior

CM Reichel, JD Linkugel, RA Bevins - Pharmacology Biochemistry and …, 2008 - Elsevier
Bupropion reduces the subjective effects and cue-induced craving for methamphetamine in
humans. Given these effects of bupropion on methamphetamine in humans and its …

Inhibition of a cortico-thalamic circuit attenuates cue-induced reinstatement of drug-seeking behavior in “relapse prone” male rats

BN Kuhn, P Campus, MS Klumpner, SE Chang… - …, 2022 - Springer
Rationale Relapse often occurs when individuals are exposed to stimuli or cues previously
associated with the drug-taking experience. The ability of drug cues to trigger relapse is …

Sign-tracking behavior is difficult to extinguish and resistant to multiple cognitive enhancers

CJ Fitzpatrick, T Geary, JF Creeden… - Neurobiology of learning …, 2019 - Elsevier
The attribution of incentive-motivational value to drug-related cues underlies relapse and
craving in drug addiction. One method of addiction treatment, cue-exposure therapy, utilizes …

Understanding the stimulus effects of nicotine and bupropion in a drug-drug discriminated goal-tracking task

AE Moran, YW Huynh, AP Finkner, C Selleck… - …, 2022 - Springer
Rationale Bupropion is a non-nicotine medication for smoking cessation that has
overlapping stimulus effects with nicotine as demonstrated in drug discrimination studies …

Cue-induced reinstatement of nicotine-seeking behavior in rats: effect of bupropion, persistence over repeated tests, and its dependence on training dose

X Liu, AR Caggiula, MI Palmatier, EC Donny… - …, 2008 - Springer
Rationale The motivational effects of nicotine-associated cues have been demonstrated in
animal studies. However, it is unknown whether the effectiveness of nicotine cues in …

PRECLINICAL STUDY: Pavlovian drug discrimination with bupropion as a feature positive occasion setter: substitution by methamphetamine and nicotine, but not …

JL Wilkinson, C Li, RA Bevins - Addiction biology, 2009 - Wiley Online Library
Bupropion can serve as a discriminative stimulus (SD) in an operant drug discrimination
task, and a variety of stimulants substitute for the bupropion SD. There are no reports …

Effects of two kinds of noradrenergic ADHD medicines on sign-tracking and goal-tracking in male rats.

JM Holden - Experimental and Clinical Psychopharmacology, 2022 - psycnet.apa.org
Sign-and goal-tracking are behaviors seen in many species when a conditioned stimulus
and it's corresponding unconditioned stimulus are presented at separate locations, and …