Background & Aims Although the healthy pancreas consists mostly of epithelial cells,
pancreatic cancer and the precursor lesions known as pancreatic intraepithelial neoplasia …

Pancreatic cancer is characterized by abundant desmoplasia, a dense stroma composed of
extra-cellular and cellular components, with cancer associated fibroblasts (CAFs) being the …

Pancreatic ductal adenocarcinoma (PDA) is characterized by an extensive fibroinflammatory
microenvironment that accumulates from the onset of disease progression. Cancer …

Pancreatic tumors are known to harbor an abundant and highly desmoplastic stroma.
Among the various cell types that reside within tumor stroma, cancer-associated fibroblasts …

Simple Summary Cancer-associated fibroblasts, which are derived from several cell types
such as pancreatic stellate cells or mesenchymal stem cells, play a major role in the …

Simple Summary Pancreatic cancer is a very deadly form of cancer with a low survival rate.
One important characteristic of pancreatic cancer is the presence of a dense tissue called …

Background & Aims Oncogenic Kirsten Rat Sarcoma virus (KRAS) is the hallmark mutation
of human pancreatic cancer and a driver of tumorigenesis in genetically engineered mouse …

Simple Summary The tumor microenvironment plays a major role in the progression and
drug resistance of pancreatic cancer. Cancer-associated fibroblasts are the major stromal …

Pancreatic cancer is one of the most lethal malignancies. Significant progresses have been
made in understanding of pancreatic cancer pathogenesis, including appreciation of …

Fibroblasts display extensive transcriptional heterogeneity, yet functional annotation and
characterization of their heterocellular relationships remains incomplete. Using mass …