Defects in nucleocytoplasmic transport have been associated with several
neurodegenerative disorders and, in particular, the formation of pathological protein …

Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease
characterized by degeneration of upper and lower motor neurons in the brain and spinal …

The nuclear pore is the gatekeeper of nucleocytoplasmic transport and signaling through
which a vast flux of information is continuously exchanged between the nuclear and …

The widespread nature of nucleocytoplasmic trafficking defects and protein accumulation
suggests distinct yet overlapping mechanisms in a variety of neurodegenerative diseases …

Neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), frontotemporal
dementia (FTD), and Huntington's disease (HD), are characterized by intracellular …

Nucleocytoplasmic transport (NCT) across the nuclear envelope is precisely regulated in
eukaryotic cells, and it plays critical roles in maintenance of cellular homeostasis …

An astonishing number of neurological diseases result from expansion of unstable repetitive
sequences causing alterations in key neuronal processes. Some are progressive late-onset …

In the ongoing process of uncovering molecular abnormalities in neurodegenerative
diseases characterized by toxic protein aggregates, nucleo-cytoplasmic transport defects …

Many neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis are characterized by the accumulation of pathogenic proteins …

There is ample evidence that nucleocytoplasmic-transport deficits could play an important
role in the pathology of amyotrophic lateral sclerosis (ALS). However, the currently available …