Lipodystrophies: genetic and acquired body fat disorders

A Garg - The Journal of Clinical Endocrinology & Metabolism, 2011 - academic.oup.com
Context: Lipodystrophies are heterogeneous, genetic or acquired disorders characterized by
selective loss of body fat and predisposition to insulin resistance. The extent of fat loss …

Familial partial lipodystrophy (FPLD): recent insights

C Bagias, A Xiarchou, A Bargiota… - … , Metabolic Syndrome and …, 2020 - Taylor & Francis
Lipodystrophies are a heterogeneous group of congenital or acquired disorders,
characterized by partial or generalized loss of adipose tissue. Familial partial lipodystrophy …

Genetic basis of lipodystrophies and management of metabolic complications

AK Agarwal, A Garg - Annu. Rev. Med., 2006 - annualreviews.org
Selective loss of body fat is the hallmark of patients with lipodystrophies. Among genetic
lipodystrophies, fat loss is observed either from birth, as in congenital generalized …

Acquired and inherited lipodystrophies

A Garg - New England Journal of Medicine, 2004 - Mass Medical Soc
Lipodystrophies, heterogeneous acquired or inherited disorders characterized by the
selective loss of adipose tissue, predispose affected patients to insulin resistance and its …

Congenital generalized lipodystrophies—new insights into metabolic dysfunction

N Patni, A Garg - Nature Reviews Endocrinology, 2015 - nature.com
Congenital generalized lipodystrophy (CGL) is a heterogeneous autosomal recessive
disorder characterized by a near complete lack of adipose tissue from birth and, later in life …

[HTML][HTML] Thematic review series: Adipocyte Biology. Lipodystrophies: windows on adipose biology and metabolism

RA Hegele, TR Joy, SA Al-Attar, BK Rutt - Journal of lipid research, 2007 - ASBMB
The lipodystrophies are characterized by loss of adipose tissue in some anatomical sites,
frequently with fat accumulation in nonatrophic depots and ectopic sites such as liver and …

Clinical classification and treatment of congenital and acquired lipodystrophy

JL Chan, EA Oral - Endocrine Practice, 2010 - Elsevier
Objective To review the initial clinical manifestations of congenital and acquired
lipodystrophy syndromes, discuss novel classifications associated with genetic mutations …

[HTML][HTML] Diagnosis and treatment of lipodystrophy: a step-by-step approach

D Araújo-Vilar, F Santini - Journal of endocrinological investigation, 2019 - Springer
Aim Lipodystrophy syndromes are rare heterogeneous disorders characterized by
deficiency of adipose tissue, usually a decrease in leptin levels and, frequently, severe …

[HTML][HTML] Exploring the pathophysiology behind the more common genetic and acquired lipodystrophies

T Nolis - Journal of human genetics, 2014 - nature.com
Lipodystrophies are an immense group of genetic or acquired metabolic disorders that are
characterized by varying degrees of body fat loss and in some instances localized …

Phenotypic and genetic characteristics of lipodystrophy: pathophysiology, metabolic abnormalities, and comorbidities

B Akinci, R Meral, EA Oral - Current Diabetes Reports, 2018 - Springer
Purpose of review This article focuses on recent progress in understanding the genetics of
lipodystrophy syndromes, the pathophysiology of severe metabolic abnormalities caused by …