All women undergo the menopause transition (MT), a neuro-endocrinological process that
impacts aging trajectories of multiple organ systems including brain. The MT occurs over …

Along with advanced age and apolipoprotein E (APOE)-4 genotype, female sex is a major
risk factor for developing late-onset Alzheimer's disease (AD). Considering that AD …

After advanced age, female sex is the major risk factor for Alzheimer's disease (AD). The
biological mechanisms underlying the increased AD risk in women remain largely …

Two thirds of all persons with late-onset Alzheimer's disease (AD) are women. Identification
of sex-based molecular mechanisms underpinning the female-based prevalence of AD …

Ovarian hormones, particularly 17β-estradiol, are involved in numerous neurophysiological
and neurochemical processes, including those subserving cognitive function. Estradiol plays …

Estrogen is a fundamental regulator of the metabolic system of the female brain and body.
Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial …

The perimenopause is an aging transition unique to the female that leads to reproductive
senescence which can be characterized by multiple neurological symptoms. To better …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder, the development of
which is regulated by several environmental and genetic risk factors. Two factors theorized …

Ovarian hormones have substantial effects on the brain, and early menopause has been
associated with increased risk of accelerated brain aging and dementia later in life …

Most studies of menopause and brain aging have focused on the role of the sex steroid
hormone, estradiol, as a key mechanisms contributing to cognitive and brain aging in …