Voltage-gated Ca 2+ channels couple membrane depolarization to Ca 2+-dependent
intracellular signaling events. This is achieved by mediating Ca 2+ ion influx or by direct …

Voltage-gated L-type Ca2+ channels (LTCCs) mediate depolarization-induced Ca2+ entry
in electrically excitable cells, including muscle cells, neurons, and endocrine and sensory …

Within the voltage-gated calcium channels (Cav channels) family, there are four genes
coding for the L-type Cav channels (Cav1). The Cav1 channels underly many important …

Voltage-gated calcium channels (VGCCs) mediate calcium entry into excitable cells in
response to membrane depolarization. During the past decade, our understanding of the …

The use of specific activators and inhibitors that penetrate the central nervous system has
suggested an essential functional role of L-type calcium channels (LTCC) in several …

Mutations of human Ca V 1.2 channel gene were identified only recently. The gain-of-
function mutations were found at two mutually exclusive exons in patients with Timothy …

Voltage-gated L-type Ca 2+ channels (LTCCs) containing a pore-forming α1D subunit (D-
LTCCs) are expressed in neurons and neuroendocrine cells. Their relative contribution to …

L‐type calcium channels (Cav1) represent one of the three major classes (Cav1–3) of
voltage‐gated calcium channels. They were identified as the target of clinically used calcium …

Activity of voltage-gated Ca v 1.3 L-type Ca 2+ channels is required for proper hearing as
well as sinoatrial node and brain function. This critically depends on their negative activation …

The voltage-gated L-type calcium channel (LTCC) is essential for multiple cellular
processes. In the heart, calcium influx through LTCC plays an important role in cardiac …