For decades, great strides have been made in the field of immunometabolism. A plethora of
evidence ranging from basic mechanisms to clinical transformation has gradually embarked …

Despite improved treatment options, cancer remains the leading cause of morbidity and
mortality worldwide, with 90% of this mortality correlated to the development of metastasis …

The metabolic reprogramming of tumor cells and immune escape are two major hallmarks of
cancer cells. The metabolic changes that occur during tumorigenesis, enabling survival and …

Immunometabolism, which studies cellular metabolism and immune cell function, is a
possible cancer treatment. Metabolic pathways regulate immune cell activation …

Despite rapid advances in the field of immunotherapy, the elimination of established tumors
has not been achieved. Many promising new treatments such as adoptive cell therapy (ACT) …

With the significant successes of immune checkpoint blockade and adoptive cellular
therapy, immunotherapy has now become an established treatment option to effectively treat …

Here, we explore the manipulation of immune cell metabolism as a strategy in target
discovery and drug development for immune-mediated diseases. Comparing exploitation of …

During an immune response, leukocytes undergo major changes in growth and function that
are tightly coupled to dynamic shifts in metabolic processes. Immunometabolism is an …

Cancer is a complex succession of disease progressively associated with uncontrolled
growth and capability of cells eluding the body's natural mechanism of defense and cell …

Through the successes of checkpoint blockade and adoptive cellular therapy,
immunotherapy has become an established treatment modality for cancer. Cellular …