Glycolysis rate-limiting enzymes: novel potential regulators of rheumatoid arthritis pathogenesis

J Zuo, J Tang, M Lu, Z Zhou, Y Li, H Tian, E Liu… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a classic autoimmune disease characterized by uncontrolled
synovial proliferation, pannus formation, cartilage injury, and bone destruction. The specific …

A new strategy for osteoarthritis therapy: Inhibition of glycolysis

C Tan, L Li, J Han, K Xu, X Liu - Frontiers in Pharmacology, 2022 - frontiersin.org
Osteoarthritis (OA) is a common degenerative disease of the joints. It is primarily caused by
age, obesity, mechanical damage, genetics, and other factors, leading to cartilage …

Role of glucose metabolism in aggressive phenotype of fibroblast-like synoviocytes: Latest evidence and therapeutic approaches in rheumatoid arthritis

M Masoumi, M Mehrabzadeh, S Mahmoudzehi… - International …, 2020 - Elsevier
Glucose metabolism is considerably increased in inflamed joints of rheumatoid arthritis (RA)
patients at early stages. Fibroblast-like synoviocytes (FLSs) activation and subsequent joint …

Inhibition of 6‐phosphofructo‐2‐kinase suppresses fibroblast‐like synoviocytes‐mediated synovial inflammation and joint destruction in rheumatoid arthritis

Y Zou, S Zeng, M Huang, Q Qiu, Y Xiao… - British Journal of …, 2017 - Wiley Online Library
Background and Purpose Abnormal glycolytic metabolism contributes to joint inflammation
in rheumatoid arthritis (RA). The aims of this study were to investigate the role of 6 …

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

Z Yang, H Fujii, SV Mohan, JJ Goronzy… - Journal of Experimental …, 2013 - rupress.org
In the HLA class II–associated autoimmune syndrome rheumatoid arthritis (RA), CD4 T cells
are critical drivers of pathogenic immunity. We have explored the metabolic activity of RA T …

Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis

MF Bustamante, PG Oliveira… - Annals of the …, 2018 - ard.bmj.com
Objectives Recent studies indicate that glucose metabolism is altered in rheumatoid arthritis
(RA) fibroblast-like synoviocytes (FLS). Hexokinases (HKs) catalyse the first step in glucose …

PKM2: a potential regulator of rheumatoid arthritis via glycolytic and non-glycolytic pathways

D Xu, J Liang, J Lin, C Yu - Frontiers in immunology, 2019 - frontiersin.org
Immunometabolism provides a new perspective on the pathogenesis of rheumatoid arthritis
(RA). In recent years, there have been investigations focusing on the role of intracellular …

HK2: a potential regulator of osteoarthritis via glycolytic and non-glycolytic pathways

C Bao, S Zhu, K Song, C He - Cell Communication and Signaling, 2022 - Springer
Osteoarthritis (OA) is an age-related chronic degenerative joint disease where the main
characteristics include progressive degeneration of cartilage, varying degrees of synovitis …

Inhibition of hexokinases holds potential as treatment strategy for rheumatoid arthritis

G Song, Q Lu, H Fan, X Zhang, L Ge, R Tian… - Arthritis Research & …, 2019 - Springer
Introduction Abnormal glycolytic metabolism contributes to joint inflammation and
destruction in rheumatoid arthritis (RA). We examine the expression and function of …

Fibroblast-like synoviocytes glucose metabolism as a therapeutic target in rheumatoid arthritis

PG De Oliveira, M Farinon, E Sanchez-Lopez… - Frontiers in …, 2019 - frontiersin.org
Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic
disruption that may be therapeutically targetable. Among them, glucose metabolism and …