We show here that the combination of interferon-β (IFN-β) and all-trans-retinoic acid (RA)
induces the death of tumor cells. To understand the molecular basis for synergistic growth …

GRIM-19 (gene associated with retinoid-IFN-induced mortality 19), isolated as a cell death
activator in a genetic screen used to define mechanisms involved in IFN-β-and retinoic acid …

Cytokines and vitamins play a central role in controlling neoplastic cell growth. The
interferon (IFN) family of cytokines regulates antiviral, anti-tumor, antimicrobial …

Interferons (IFNs) and retinoids are potent biological response modifiers. By using JAK-
STAT pathways, IFNs regulate the expression of genes involved in antiviral, antitumor, and …

Signal transducer and activator of transcription 3 (Stat3) is a latent cytoplasmic transcription
factor that can be activated by cytokines and growth factors. Stat3 plays important roles in …

Gene associated with retinoid-IFN-induced mortality 19 (GRIM-19), as a novel IFN-β/RA-
inducible gene product, was identified as a potential tumor suppressor associated with …

Signal transducers and activators of transcription 3 (STAT3) was originally identified as a
transcription factor that mediates cytokine-induced responses. In these pathways, Janus …

Gene associated with retinoid interferon-induced mortality (GRIM)-19, an inhibitor of
transcription factor STAT3, was originally identified as a critical regulatory protein in a …

Cervical cancer is the most common malignant disease responsible for the deaths of a large
number of women in the developing world. Although certain strains of human papillomavirus …

GW112 is a novel gene that has little homology to other known genes. It is overexpressed in
a number of human tumor types, especially in those of the digestive system. We show here …