Engineered human cardiac tissues facilitate progress in regenerative medicine, disease
modelling and drug development. In this Perspective, we reflect on the most notable …

During an average individual's lifespan, the human heart pumps nearly 200 million liters of
blood delivered by approximately 3 billion heartbeats. Therefore, it is not surprising that …

[Frontiers in Bioscience 17, 1533-1550, January 1, 2012] 1533 Cardiac tissue engineering:
current state and perspectives Loraine Page 1 [Frontiers in Bioscience 17, 1533-1550 …

In recent years, the development of 3-dimensional engineered heart tissue (EHT) has made
large strides forward because of advances in stem cell biology, materials science …

The adult heart is a vital and highly specialized organ of the human body, with limited
capability of self-repair and regeneration in case of injury or disease. Engineering …

The promise of cardiac tissue engineering is in the ability to recapitulate in vitro the
functional aspects of a healthy heart and disease pathology as well as to design …

The advances in biotechnology, biomechanics, and biomaterials can be used to develop
organ models that aim to accurately emulate their natural counterparts. Heart disease, one …

Cardiovascular diseases are the major cause of death worldwide. The heart has limited
capacity of regeneration, therefore, transplantation is the only solution in some cases …

Cardiac tissue engineering aims to create functional tissue constructs that can reestablish
the structure and function of injured myocardium. Engineered constructs can also serve as …

Cardiovascular disease is the number one killer worldwide, with myocardial infarction (MI)
responsible for approximately 1 in 6 deaths. The lack of endogenous regenerative capacity …