The ubiquitin-proteasome system (UPS) is the major non-lysosomal proteolytic system for
the degradation of abnormal or damaged proteins no longer required. The proteasome is …

The immunoproteasome is predominantly expressed in monocytes and lymphocytes and is
responsible for the generation of antigenic peptides for cell-mediated immunity. Upon the …

The immunoproteasome, a specialized form of proteasome, is mainly expressed in
lymphocytes and monocytes of jawed vertebrates and responsible for the generation of …

The proteasome, a large multisubunit protease complex, has been extensively investigated
over the years, greatly enhancing our understanding of critical roles that the proteasome …

Suppression of proteasome function with the first-in-class small molecule inhibitor
bortezomib is a rational therapeutic strategy against several hematologic malignancies …

The ubiquitin-proteasome system (UPS) plays a vital role in maintaining protein
homeostasis and regulating numerous cellular processes. The proteasome, a multi-protease …

The ubiquitin–proteasome system (UPS) is a central part of protein homeostasis, degrading
not only misfolded or oxidized proteins but also proteins with essential functions. The fact …

The immunoproteasome is a highly efficient proteolytic machinery derived from the
constitutive proteasome and is abundantly expressed in immune cells. The …

Proteasome inhibition is a validated strategy for therapy of multiple myeloma, but this
disease remains challenging as relapses are common, and often associated with increasing …

The proteasome is a multicatalytic protease complex that mediates the controlled
degradation of intracellular proteins, including key components of pathways that contribute …