Genotype imputation with thousands of genomes
Genotype imputation is a statistical technique that is often used to increase the power and
resolution of genetic association studies. Imputation methods work by using haplotype …
resolution of genetic association studies. Imputation methods work by using haplotype …
[HTML][HTML] A one-penny imputed genome from next-generation reference panels
Genotype imputation is commonly performed in genome-wide association studies because it
greatly increases the number of markers that can be tested for association with a trait. In …
greatly increases the number of markers that can be tested for association with a trait. In …
Genotype imputation from large reference panels
Genotype imputation has become a standard tool in genome-wide association studies
because it enables researchers to inexpensively approximate whole-genome sequence …
because it enables researchers to inexpensively approximate whole-genome sequence …
A flexible and accurate genotype imputation method for the next generation of genome-wide association studies
BN Howie, P Donnelly, J Marchini - PLoS genetics, 2009 - journals.plos.org
Genotype imputation methods are now being widely used in the analysis of genome-wide
association studies. Most imputation analyses to date have used the HapMap as a reference …
association studies. Most imputation analyses to date have used the HapMap as a reference …
minimac2: faster genotype imputation
Genotype imputation is a key step in the analysis of genome-wide association studies.
Upcoming very large reference panels, such as those from The 1000 Genomes Project and …
Upcoming very large reference panels, such as those from The 1000 Genomes Project and …
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing
Abstract The 1000 Genomes Project and disease-specific sequencing efforts are producing
large collections of haplotypes that can be used as reference panels for genotype imputation …
large collections of haplotypes that can be used as reference panels for genotype imputation …
Next-generation genotype imputation service and methods
Genotype imputation is a key component of genetic association studies, where it increases
power, facilitates meta-analysis, and aids interpretation of signals. Genotype imputation is …
power, facilitates meta-analysis, and aids interpretation of signals. Genotype imputation is …
Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel
O Delaneau, J Marchini - Nature communications, 2014 - nature.com
A major use of the 1000 Genomes Project (1000GP) data is genotype imputation in genome-
wide association studies (GWAS). Here we develop a method to estimate haplotypes from …
wide association studies (GWAS). Here we develop a method to estimate haplotypes from …
[HTML][HTML] Using linear predictors to impute allele frequencies from summary or pooled genotype data
X Wen, M Stephens - The annals of applied statistics, 2010 - ncbi.nlm.nih.gov
Recently-developed genotype imputation methods are a powerful tool for detecting untyped
genetic variants that affect disease susceptibility in genetic association studies. However …
genetic variants that affect disease susceptibility in genetic association studies. However …
A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals
BL Browning, SR Browning - The American Journal of Human Genetics, 2009 - cell.com
We present methods for imputing data for ungenotyped markers and for inferring haplotype
phase in large data sets of unrelated individuals and parent-offspring trios. Our methods …
phase in large data sets of unrelated individuals and parent-offspring trios. Our methods …