Cancer immunotherapy holds great promise for the treatment of solid tumors, but its
effectiveness is hindered by the recruitment of regulatory T cells (Tregs), which inhibit anti …

Double-stranded DNA (dsDNA) in the cytoplasm of eukaryotic cells is abnormal and typically
indicates the presence of pathogens or mislocalized self-DNA. Multiple sensors detect …

Chronic activation of inflammatory pathways and suppressed interferon signaling are
hallmarks of myeloid cells in immunosuppressive tumors that drive poor responsiveness to …

The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is
triggered by the sensing of cytosolic DNA, triggering the production of type I interferon (IFN-I) …

Background Stimulator of interferon genes (STING) is an innate immune sensor of
cytoplasmic double-stranded DNA originating from microorganisms and host cells. The …

The innate immune sensing of nucleic acids using effective immunoadjuvants is critical for
increasing protective immune responses against cancer. Stimulators of interferon genes …

Background While stimulator of interferon genes (STING) activation in innate immune cells
of the tumor microenvironment can result in CD8 T cell-dependent antitumor immunity …

A pre-existing T cell-inflamed tumor microenvironment has prognostic utility and also can be
predictive for response to contemporary cancer immunotherapies. The generation of a …

A substantial fraction of cancers evade immune detection by silencing Stimulator of
Interferon Genes (STING)-Interferon (IFN) signaling. Therapeutic reactivation of this program …

Stimulator of interferon genes (STING), a major adaptor protein in antiviral innate immune
signaling, is considered as one of the most important regulators of antiviral and antitumor …