The incidence of cutaneous melanoma is rapidly increasing worldwide. Cutaneous
melanoma is an aggressive type of skin cancer, which originates from malignant …

Background Hyaluronan is an extracellular matrix glycosaminoglycan involved in invasion,
proliferation and metastasis of various types of carcinomas. In many cancers, aberrant …

Background Hyaluronan is a large extracellular matrix molecule involved in several
biological processes such as proliferation, migration and invasion. In many cancers …

Cancers are supported by a distinct type of connective tissue stroma, crucial for tumor
survival and advancement. Hyaluronan is a major matrix molecule in the stroma of many …

Hyaluronan (HA) synthesis is a tightly regulated process and is partly controlled by the
microenvironment (eg, lactate concentration). Experimental evidence has indicated that the …

Hyaluronan, a major macropolysaccharide in the extracellular matrix of connective tissues,
is intimately involved in the biology of cancer. Hyaluronan accumulates into the stroma of …

The extracellular matrix is part of the microenvironment and its functions are associated with
the physical and chemical properties of the tissue. Among the extracellular components, the …

Malignant skin melanoma is one of the most deadly human cancers. Extracellular matrix
(ECM) influences the growth of malignant tumors by modulating tumor cells adhesion and …

In many cancers hyaluronan content is increased, either by tumor cells or the surrounding
stromal cells and this increased hyaluronan content correlates with unfavorable clinical …

Hyaluronate plays a unique role in the cancer cell microenvironment. In particular,
melanoma is the tumor type in which hyaluronate and hyaluronate recognition have been …