Ageing, infections and inflammation result in oxidative stress that can irreversibly damage
cellular structures. The oxidative damage of lipids in membranes or lipoproteins is one of …

Lipid peroxidation occurs in the context of many physiological processes but is greatly
increased in various pathological situations. A consequence of phospholipid peroxidation is …

Oxidative stress has been hypothesized to contribute to the development of age-related
macular degeneration (AMD), the most common cause of blindness in the United States. At …

Lipid peroxidation is a common event in health and is greatly accelerated in pro-
inflammatory settings such as hypercholesterolemia. Consequently, oxidation-specific …

Accumulating evidence suggests that oxidation-specific epitopes (OSEs) constitute a novel
class of damage-associated molecular patterns (DAMPs) generated during high oxidative …

Oxidation reactions are vital parts of metabolism and signal transduction. However, they also
produce reactive oxygen species, which damage lipids, proteins and DNA, generating …

Glycerophospholipids represent a common class of lipids critically important for integrity of
cellular membranes. Oxidation of esterified unsaturated fatty acids dramatically changes …

Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of
oxidized lipoproteins and apoptotic cells. Adaptive immune responses to various oxidation …

Abstract Age-related Macular Degeneration (AMD) is the leading cause of blindness among
the elderly in western societies. While antioxidant micronutrient treatment is available for …

A hallmark of aging is an imbalance between production and clearance of reactive oxygen
species and increased levels of oxidatively damaged biomolecules. Herein, we demonstrate …