[HTML][HTML] A random six-phase switch regulates pneumococcal virulence via global epigenetic changes
Streptococcus pneumoniae (the pneumococcus) is the world's foremost bacterial pathogen
in both morbidity and mortality. Switching between phenotypic forms (or 'phases') that favour …
in both morbidity and mortality. Switching between phenotypic forms (or 'phases') that favour …
[HTML][HTML] Epigenetic Switch Driven by DNA Inversions Dictates Phase Variation in Streptococcus pneumoniae
DNA methylation is an important epigenetic mechanism for phenotypic diversification in all
forms of life. We previously described remarkable cell-to-cell heterogeneity in epigenetic …
forms of life. We previously described remarkable cell-to-cell heterogeneity in epigenetic …
[HTML][HTML] Mechanisms of genome evolution of Streptococcus
The genus Streptococcus contains 104 recognized species, many of which are associated
with human or animal hosts. A globally prevalent human pathogen in this group is …
with human or animal hosts. A globally prevalent human pathogen in this group is …
[HTML][HTML] A high-resolution view of genome-wide pneumococcal transformation
Transformation is an important mechanism of microbial evolution through which bacteria
have been observed to rapidly adapt in response to clinical interventions; examples include …
have been observed to rapidly adapt in response to clinical interventions; examples include …
[HTML][HTML] Diversification of bacterial genome content through distinct mechanisms over different timescales
NJ Croucher, PG Coupland, AE Stevenson… - Nature …, 2014 - nature.com
Bacterial populations often consist of multiple co-circulating lineages. Determining how such
population structures arise requires understanding what drives bacterial diversification …
population structures arise requires understanding what drives bacterial diversification …
[HTML][HTML] Synthetic genetic oscillators demonstrate the functional importance of phenotypic variation in pneumococcal-host interactions
AS Rueff, R Van Raaphorst, SD Aggarwal… - Nature …, 2023 - nature.com
Phenotypic variation is the phenomenon in which clonal cells display different traits even
under identical environmental conditions. This plasticity is thought to be important for …
under identical environmental conditions. This plasticity is thought to be important for …
Natural transformation and genome evolution in Streptococcus pneumoniae
D Straume, GA Stamsås, LS Håvarstein - Infection, Genetics and Evolution, 2015 - Elsevier
Streptococcus pneumoniae is a frequent colonizer of the human nasopharynx that has the
potential to cause severe infections such as pneumonia, bacteremia and meningitis. Despite …
potential to cause severe infections such as pneumonia, bacteremia and meningitis. Despite …
[HTML][HTML] Programmed protection of foreign DNA from restriction allows pathogenicity island exchange during pneumococcal transformation
C Johnston, B Martin, C Granadel, P Polard… - PLoS …, 2013 - journals.plos.org
In bacteria, transformation and restriction-modification (RM) systems play potentially
antagonistic roles. While the former, proposed as a form of sexuality, relies on internalized …
antagonistic roles. While the former, proposed as a form of sexuality, relies on internalized …
[HTML][HTML] Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant Streptococcus pneumoniae serotype 14
Background Streptococcus pneumoniae serotype 14 is one of the most common
pneumococcal serotypes that cause invasive pneumococcal diseases worldwide. Serotype …
pneumococcal serotypes that cause invasive pneumococcal diseases worldwide. Serotype …
[HTML][HTML] Pneumococcal within-host diversity during colonization, transmission and treatment
Characterizing the genetic diversity of pathogens within the host promises to greatly improve
surveillance and reconstruction of transmission chains. For bacteria, it also informs our …
surveillance and reconstruction of transmission chains. For bacteria, it also informs our …