Antibodies play an essential role in host defence against pathogens by recognizing
microorganisms or infected cells. Although preventing pathogen entry is one potential …

Induction of pathogen-specific binding antibodies has long been considered a signature of
protective immunity following vaccination and infection. The humoral immune response is a …

Antibodies can impact pathogens in the presence or in the absence of effector cells or
effector molecules such as complement, and experiments can often sort out with precision …

Innate host defense pathways consist of microbial sensors, their signaling pathways, and the
antimicrobial effector mechanisms. Several classes of host defense pathways are currently …

Antibodies are important tools for experimental research and medical applications. Most
antibodies are composed of two heavy and two light chains. Both chains contribute to the …

Antibodies and Fc-fusion antibody-like proteins have become successful biologics
developed for cancer treatment, passive immunity against infection, addiction, and …

The adaptive humoral immune response is responsible for the generation of antimicrobial
proteins known as immunoglobulin molecules or antibodies. Immunoglobulins provide a …

In the last decades of the 20th century, infectious diseases have re-emerged as a significant
public health problem in the developed world. However, the available anti-infective …

Despite the hurdles of identifying effective targets and understanding how mAbs provide
protection within different infections, we show that the progress made in these fields is a …

Antibodies are the cardinal effector molecules of the immune system and are being
leveraged with enormous success as biotherapeutic drugs. A key part of the adaptive …