Sleep is universal, tightly regulated, and its loss impairs cognition. But why does the brain
need to disconnect from the environment for hours every day? The synaptic homeostasis …

Sleep is universal, tightly regulated, and many cognitive functions are impaired if we do not
sleep. But why? Why do our brains need to disconnect from the environment for hours every …

It is commonly accepted that brain plasticity occurs in wakefulness and sleep. However, how
these different brain states work in concert to create long-lasting changes in brain circuitry is …

Sleep is a fundamental and evolutionarily conserved aspect of animal life. Recent studies
have shed light on the role of sleep in synaptic plasticity. Demonstrations of memory replay …

Research findings over the past two decades have supported a link between sleep states
and synaptic plasticity. Numerous mechanistic hypotheses have been put forth to explain …

Sleep must serve an essential, universal function, one that offsets the risk of being
disconnected from the environment. The synaptic homeostasis hypothesis (SHY) is an …

Sleep requires that we disconnect from the environment, losing the ability to promptly
respond to stimuli. There must be at least one essential function that justifies why we take …

Sleep has been ascribed a critical role in cognitive functioning. Several lines of evidence
implicate sleep in the consolidation of synaptic plasticity and long-term memory. Stress …

Recent evidence indicates that net synaptic strength in cortical and other networks increases
during wakefulness and returns to a baseline level during sleep. These homeostatic …

While there is ample agreement that the cognitive role of sleep is explained by sleep-
dependent synaptic changes, consensus is yet to be established as to the nature of these …